ST段抬高型心肌梗死患者血清白细胞介素-39升高与左心室收缩功能障碍有关。
Elevated serum IL-39 in patients with ST-segment elevation myocardial infarction was related with left ventricular systolic dysfunction.
作者信息
Luo Yu, Liu Feng, Liu Huadong, Chen Hongdan, Cheng Wenfei, Dong Shaohong, Xiong Wei
机构信息
Department of Gerontology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China.
Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China.
出版信息
Biomark Med. 2017 May;11(6):419-426. doi: 10.2217/bmm-2016-0361. Epub 2017 Apr 5.
AIM
To investigate the changes and significance of circulating IL-39 in patients with acute coronary syndrome (ACS).
PATIENTS & METHODS: Serum IL-39 levels in ACS patients and normal coronary arteries were measured. The correlations of IL-39 with high-sensitivity CRP, cTnI, N-terminal of the prohormone brain natriuretic peptide (NTproBNP) and left ventricular ejection fraction were investigated.
RESULTS
The serum levels of IL-39 in ACS patients were significantly increased. IL-39 levels were positively correlated with NTproBNP, high-sensitivity CRP and cTnI, negatively correlated with left ventricular ejection fraction in ACS patients. The most significant correlation arose between serum IL-39 and NTproBNP in STEMI patients (r = 0.8309; p < 0.0001).
CONCLUSION
Circulating level of IL-39 might be a predictor of cardiac systolic dysfunction in ST-segment elevation myocardial infarction patients.
目的
探讨急性冠状动脉综合征（ACS）患者循环白细胞介素-39（IL-39）的变化及其意义。
患者与方法
检测ACS患者和正常冠状动脉患者血清IL-39水平。研究IL-39与高敏C反应蛋白（hs-CRP）、心肌肌钙蛋白I（cTnI）、脑钠肽前体N末端（NTproBNP）及左心室射血分数的相关性。
结果
ACS患者血清IL-39水平显著升高。ACS患者中，IL-39水平与NTproBNP、hs-CRP和cTnI呈正相关，与左心室射血分数呈负相关。ST段抬高型心肌梗死（STEMI）患者血清IL-39与NTproBNP之间的相关性最为显著（r = 0.8309；p < 0.0001）。
结论
IL-39的循环水平可能是ST段抬高型心肌梗死患者心脏收缩功能障碍的一个预测指标。
Zotero 插件