Sari Aysegul, Dogan Serdar, Nibali Luigi, Koseoglu Serhat
Department of Periodontology, Faculty of Dentistry, Hatay Mustafa Kemal University, Hatay, Turkey.
Periodontology Unit, Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
Clin Oral Investig. 2022 Dec;26(12):7209-7218. doi: 10.1007/s00784-022-04681-w. Epub 2022 Aug 20.
IL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1β and periostin.
Sixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals: the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1β, and periostin levels were examined using the enzyme-linked immunosorbent assay.
GCF IL‑1β, periostin, and IL-39 levels were higher in the P and G groups than in the PH group (p < 0.001). Positive correlations were detected between all GCF biochemical parameters and clinical periodontal parameters (p < 0.05). In the multivariate generalized linear regression analysis, the P (β = 37.6, 95% CI = 22.9-52.4) and G (β = 28.4, 95% CI = 15.8-41) groups were associated with GCF IL-39 levels (p < 0.001).
IL-39 levels were elevated in the presence of periodontal disease paralleling the increase in IL‑1β and periostin levels. IL-39 may have a role in the periodontal inflammation process.
IL-39, a new cytokine from the IL-12 family, can be a possible predictor marker of periodontal diseases.
白细胞介素（IL）-23p19/Ebi3（IL-39）被描述为一种新的IL-12家族成员。本研究旨在评估牙周疾病患者和健康者龈沟液（GCF）中IL-39水平，并将其与GCF中IL-1β和骨膜蛋白水平进行关联分析。
本研究纳入66例成年患者。研究设计包括三组，每组22人：牙周健康（PH）组、牙龈炎（G）组和牙周炎（P）组。记录临床牙周参数，并收集参与者的GCF样本。采用酶联免疫吸附测定法检测GCF中白细胞介素（IL）-39、IL-1β和骨膜蛋白水平。
P组和G组的GCF中IL-1β、骨膜蛋白和IL-39水平高于PH组（p<0.001）。所有GCF生化参数与临床牙周参数之间均检测到正相关（p<0.05）。在多变量广义线性回归分析中，P组（β=37.6，95%置信区间[CI]=22.9-52.4）和G组（β=28.4，95%CI=15.8-41）与GCF中IL-39水平相关（p<0.001）。
在牙周疾病存在的情况下，IL-39水平升高，与IL-1β和骨膜蛋白水平的增加平行。IL-39可能在牙周炎症过程中起作用。
IL-39是IL-12家族的一种新细胞因子，可能是牙周疾病的预测标志物。
