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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Jancar S, Braquet P, Sirois P

Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, Canada.

Braz J Med Biol Res. 1987;20(5):487-94.

Sensitized guinea pig lungs release substantial amounts of prostaglandin E2, 6-keto-prostaglandin F1 alpha, thromboxane B2 and leukotrienes B4 and D4 upon challenge with the specific antigen. 2. A specific Platelet Activating Factor (PAF) antagonist (BN-52021) significantly inhibited the release of these mediators from anaphylactic lungs, suggesting the existence of interactions between PAF and eicosanoids. 3. The injection of PAF into unsensitized guinea pig lungs induced the release of prostaglandin E2, thromboxane B2 and leukotrienes B4 and D4 as well as spasmogens having contractile effects on the trachea, bronchus and parenchyma strips. 4. Our studies on the mechanism of action of PAF suggest that the actions of PAF are mediated by leukotriene B4 which in turn release thromboxane A2. Recent results suggest that similar interactions between PAF and eicosanoids are likely in immune-complex hypersensitivity reaction in the rat.

致敏豚鼠肺在受到特异性抗原攻击时会释放大量前列腺素E2、6-酮-前列腺素F1α、血栓素B2以及白三烯B4和D4。2. 一种特异性血小板活化因子（PAF）拮抗剂（BN-52021）显著抑制了这些介质从过敏肺中的释放，提示PAF与类花生酸之间存在相互作用。3. 向未致敏豚鼠肺中注射PAF会诱导前列腺素E2、血栓素B2以及白三烯B4和D4的释放，以及对气管、支气管和平滑肌条具有收缩作用的致痉物质的释放。4. 我们对PAF作用机制的研究表明，PAF的作用是由白三烯B4介导的，而白三烯B4又会释放血栓素A2。最近的结果表明，PAF与类花生酸之间的类似相互作用可能也存在于大鼠的免疫复合物超敏反应中。

Jancar S, Braquet P, Sirois P

Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, Canada.

Braz J Med Biol Res. 1987;20(5):487-94.

Sensitized guinea pig lungs release substantial amounts of prostaglandin E2, 6-keto-prostaglandin F1 alpha, thromboxane B2 and leukotrienes B4 and D4 upon challenge with the specific antigen. 2. A specific Platelet Activating Factor (PAF) antagonist (BN-52021) significantly inhibited the release of these mediators from anaphylactic lungs, suggesting the existence of interactions between PAF and eicosanoids. 3. The injection of PAF into unsensitized guinea pig lungs induced the release of prostaglandin E2, thromboxane B2 and leukotrienes B4 and D4 as well as spasmogens having contractile effects on the trachea, bronchus and parenchyma strips. 4. Our studies on the mechanism of action of PAF suggest that the actions of PAF are mediated by leukotriene B4 which in turn release thromboxane A2. Recent results suggest that similar interactions between PAF and eicosanoids are likely in immune-complex hypersensitivity reaction in the rat.

致敏豚鼠肺在受到特异性抗原攻击时会释放大量前列腺素E2、6-酮-前列腺素F1α、血栓素B2以及白三烯B4和D4。2. 一种特异性血小板活化因子（PAF）拮抗剂（BN-52021）显著抑制了这些介质从过敏肺中的释放，提示PAF与类花生酸之间存在相互作用。3. 向未致敏豚鼠肺中注射PAF会诱导前列腺素E2、血栓素B2以及白三烯B4和D4的释放，以及对气管、支气管和平滑肌条具有收缩作用的致痉物质的释放。4. 我们对PAF作用机制的研究表明，PAF的作用是由白三烯B4介导的，而白三烯B4又会释放血栓素A2。最近的结果表明，PAF与类花生酸之间的类似相互作用可能也存在于大鼠的免疫复合物超敏反应中。