Uebelacker L A, Tremont G, Gillette L T, Epstein-Lubow G, Strong D R, Abrantes A M, Tyrka A R, Tran T, Gaudiano B A, Miller I W
Butler Hospital,Providence, RI,USA.
Alpert Medical School of Brown University,Providence, RI,USA.
Psychol Med. 2017 Sep;47(12):2130-2142. doi: 10.1017/S0033291717000575. Epub 2017 Apr 6.
The objective of this study was to determine whether hatha yoga is an efficacious adjunctive intervention for individuals with continued depressive symptoms despite antidepressant treatment.
We conducted a randomized controlled trial of weekly yoga classes (n = 63) v. health education classes (Healthy Living Workshop; HLW; n = 59) in individuals with elevated depression symptoms and antidepressant medication use. HLW served as an attention-control group. The intervention period was 10 weeks, with follow-up assessments 3 and 6 months afterwards. The primary outcome was depression symptom severity assessed by blind rater at 10 weeks. Secondary outcomes included depression symptoms over the entire intervention and follow-up periods, social and role functioning, general health perceptions, pain, and physical functioning.
At 10 weeks, we did not find a statistically significant difference between groups in depression symptoms (b = -0.82, s.e. = 0.88, p = 0.36). However, over the entire intervention and follow-up period, when controlling for baseline, yoga participants showed lower levels of depression than HLW participants (b = -1.38, s.e. = 0.57, p = 0.02). At 6-month follow-up, 51% of yoga participants demonstrated a response (⩾50% reduction in depression symptoms) compared with 31% of HLW participants (odds ratio = 2.31; p = 0.04). Yoga participants showed significantly better social and role functioning and general health perceptions over time.
Although we did not see a difference in depression symptoms at the end of the intervention period, yoga participants showed fewer depression symptoms over the entire follow-up period. Benefits of yoga may accumulate over time.
本研究的目的是确定哈他瑜伽对于尽管接受了抗抑郁治疗但仍有持续抑郁症状的个体是否为一种有效的辅助干预措施。
我们对抑郁症状加重且正在使用抗抑郁药物的个体进行了一项随机对照试验，比较每周瑜伽课程组（n = 63）和健康教育课程组（健康生活工作坊；HLW；n = 59）。HLW作为注意力控制组。干预期为10周，之后在3个月和6个月进行随访评估。主要结局是由盲法评估者在10周时评估的抑郁症状严重程度。次要结局包括整个干预和随访期间的抑郁症状、社会和角色功能、总体健康认知、疼痛及身体功能。
在10周时，我们未发现两组在抑郁症状方面存在统计学显著差异（b = -0.82，标准误 = 0.88，p = 0.36）。然而，在整个干预和随访期间，在控制基线后，瑜伽参与者的抑郁水平低于HLW参与者（b = -1.38，标准误 = 0.57，p = 0.02）。在6个月随访时，51%的瑜伽参与者表现出反应（抑郁症状减轻⩾50%），而HLW参与者为31%（优势比 = 2.31；p = 0.04）。随着时间推移，瑜伽参与者在社会和角色功能以及总体健康认知方面表现出明显更好的状况。
尽管在干预期结束时我们未发现抑郁症状有差异，但瑜伽参与者在整个随访期间的抑郁症状较少。瑜伽的益处可能会随着时间积累。
