Kristjansen P E, Hansen H H
Department of Oncology ONB, Finsen Institute, Copenhagen.
Eur J Cancer Clin Oncol. 1988 Mar;24(3):545-9. doi: 10.1016/s0277-5379(98)90035-9.
Ten patients with metastatic small cell lung cancer (SCLC) in the brain, shown by CT scan at time of diagnosis, were treated with systemic combination chemotherapy. Repeated CT scans were performed every 4 weeks. Seven patients were evaluable, since three patients died during the first 2-3 weeks. Significant responses on CT scans as well as neurologic improvement were demonstrated in all evaluable patients. Four of seven patients obtained a complete response in the brain, while three had partial remissions. The impact of this observation on the overall treatment strategies in SCLC has further to be defined.
十名经CT扫描在诊断时显示脑转移的小细胞肺癌（SCLC）患者接受了全身联合化疗。每4周进行一次重复CT扫描。七名患者可评估，因为三名患者在最初的2 - 3周内死亡。所有可评估患者在CT扫描上均显示出显著反应以及神经功能改善。七名患者中有四名脑内获得完全缓解，三名有部分缓解。这一观察结果对SCLC整体治疗策略的影响还有待进一步明确。
