Ito T, Kitamura H, Nakamura N, Kameda Y, Kanisawa M
Department of Pathology, Yokohama City University School of Medicine, Japan.
Virchows Arch A Pathol Anat Histopathol. 1993;423(1):13-7. doi: 10.1007/BF01606426.
Because of the marked vascular proliferation seen in brain metastases of small cell carcinoma of the lung (SCCL), we studied the morphometric and immunohistochemical characteristics of proliferating vessels in metastases from 20 autopsy cases of SCCL with brain metastasis. These were compared with those in surgically resected brain metastases of lung carcinomas, including 6 cases of SCCL, 19 cases of adenocarcinoma and 5 cases of squamous cell carcinoma. Angiogenesis in the tumours was scored by the microscopic angiogenesis grading system (MAGS). The MAGS score for autopsy and surgical metastatic lesions was highest in SCCL. Histologically, many vascular glomeruloid structures were formed in the brain metastases of SCCL, and immunohistochemistry revealed that these lesions were composed of proliferating endothelial cells and pericyte/smooth muscle cells. Immunostaining for basic fibroblast growth factor, a potent angiogenic factor, showed immunoreactivity in the tumour cells, regardless of histological type, and in the surrounding glial cells. Complex autocrine and paracrine phenomena participate in the development of metastatic cerebral lesions with vascular proliferation.
由于在肺小细胞癌（SCCL）脑转移灶中可见明显的血管增殖，我们研究了20例伴有脑转移的SCCL尸检病例转移灶中增殖血管的形态计量学和免疫组化特征。将这些结果与手术切除的肺癌脑转移灶进行比较，其中包括6例SCCL、19例腺癌和5例鳞状细胞癌。通过微血管生成分级系统（MAGS）对肿瘤中的血管生成进行评分。尸检和手术转移灶的MAGS评分在SCCL中最高。组织学上，SCCL脑转移灶中形成了许多血管肾小球样结构，免疫组化显示这些病灶由增殖的内皮细胞和周细胞/平滑肌细胞组成。对强效血管生成因子碱性成纤维细胞生长因子的免疫染色显示，无论组织学类型如何，肿瘤细胞以及周围神经胶质细胞均呈免疫反应性。复杂的自分泌和旁分泌现象参与了伴有血管增殖的转移性脑病灶的发展。
