羟基自由基对尿卟啉原的氧化作用。非卟啉产物作为尿卟啉原脱羧酶潜在抑制剂的证据。
Oxidation of uroporphyrinogens by hydroxyl radicals. Evidence for nonporphyrin products as potential inhibitors of uroporphyrinogen decarboxylase.
作者信息
Francis J E, Smith A G
机构信息
MRC Toxicology Unit, Medical Research Council Laboratories, Carshalton, England.
出版信息
FEBS Lett. 1988 Jun 20;233(2):311-4. doi: 10.1016/0014-5793(88)80449-6.
PMID:2838334
Abstract
A hydroxyl radical-generating system, hypoxanthine/xanthine oxidase/Fe-EDTA, oxidises uroporphyrinogens to uroporphyrins and to more polar nonporphyrin products. The evidence suggests that the nonporphyrin products have inhibitory activity towards mouse liver uroporphyrinogen decarboxylase which could explain some forms of human and experimental porphyrias.
摘要
一种产生羟基自由基的系统，即次黄嘌呤/黄嘌呤氧化酶/铁-乙二胺四乙酸，可将尿卟啉原氧化为尿卟啉以及更具极性的非卟啉产物。有证据表明，这些非卟啉产物对小鼠肝脏尿卟啉原脱羧酶具有抑制活性，这可能解释了某些形式的人类和实验性卟啉症。
Zotero 插件