大鼠肝脏尿卟啉原脱羧酶对卟啉原的脱羧作用。
Decarboxylation of porphyrinogens by rat liver uroporphyrinogen decarboxylase.
作者信息
Smith A G, Francis J E
出版信息
Biochem J. 1979 Nov 1;183(2):455-8. doi: 10.1042/bj1830455.
Abstract
The decarboxylations of uroporphyrinogens I and III and of heptacarboxylic, hexacarboxylic and pentacarboxylic porphyrinogens III by rat liver uroporphyrinogen decarboxylase were compared, and the results suggest that the removal of the first carboxy group from uroporphyrinogen III is a more rapid step than that from isomer I or the other substrates investigated.
摘要
比较了大鼠肝脏尿卟啉原脱羧酶对尿卟啉原I和III以及七羧酸、六羧酸和五羧酸卟啉原III的脱羧作用，结果表明，尿卟啉原III中第一个羧基的去除比异构体I或其他所研究底物中的相应步骤更快。
相似文献
1
Decarboxylation of porphyrinogens by rat liver uroporphyrinogen decarboxylase.大鼠肝脏尿卟啉原脱羧酶对卟啉原的脱羧作用。
Biochem J. 1979 Nov 1;183(2):455-8. doi: 10.1042/bj1830455.
2
Decarboxylation of uroporphyrinogen III by erythrocyte uroporphyrinogen decarboxylase. Evidence for a random decarboxylation mechanism.红细胞尿卟啉原脱羧酶对尿卟啉原III的脱羧作用。随机脱羧机制的证据。
Biochem J. 1990 Jun 1;268(2):513-5. doi: 10.1042/bj2680513.
3
Investigations of rat liver uroporphyrinogen decarboxylase. Comparisons of porphyrinogens I and III as substrates and the inhibition by porphyrins.大鼠肝脏尿卟啉原脱羧酶的研究。卟啉原I和III作为底物的比较以及卟啉的抑制作用。
Biochem J. 1981 Apr 1;195(1):241-50. doi: 10.1042/bj1950241.
4
Liver porphyrinogen carboxylase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I.六氯苯致卟啉症大鼠的肝脏卟啉原羧化酶。对Ⅲ系列中间卟啉原和尿卟啉原Ⅰ的研究。
Int J Biochem. 1987;19(4):365-72. doi: 10.1016/0020-711x(87)90010-3.
5
Tetrapyrroles as substrates and inhibitors of porphyrinogen carboxy - lyase from rat liver.四吡咯作为大鼠肝脏中卟啉原羧化酶的底物和抑制剂
Acta Physiol Lat Am. 1976;26(5):403-14.
6
Random decarboxylation of uroporphyrinogen III by human hepatic uroporphyrinogen decarboxylase.人肝脏尿卟啉原脱羧酶对尿卟啉原III的随机脱羧作用。
J Chromatogr. 1991 May 31;566(2):409-13. doi: 10.1016/0378-4347(91)80257-d.
7
In vitro studies of the mechanism of inhibition of rat liver uroporphyrinogen decarboxylase activity by ferrous iron under anaerobic conditions.在厌氧条件下亚铁离子对大鼠肝脏尿卟啉原脱羧酶活性抑制机制的体外研究
Arch Biochem Biophys. 1986 Feb 1;244(2):619-29. doi: 10.1016/0003-9861(86)90630-2.
8
Measurement of uroporphyrinogen decarboxylase using porphyrinogens prepared by chemical reduction.使用化学还原法制备的卟啉原测定尿卟啉原脱羧酶。
Enzyme. 1982;28(2-3):186-95. doi: 10.1159/000459101.
9
Some kinetic properties of human red cell uroporphyrinogen decarboxylase.人红细胞尿卟啉原脱羧酶的一些动力学特性。
Biochim Biophys Acta. 1980 Jan 11;611(1):174-86. doi: 10.1016/0005-2744(80)90053-4.
引用本文的文献
1
Uroporphyrinogen decarboxylase as a potential target for specific components of traditional Chinese medicine: a virtual screening and molecular dynamics study.尿卟啉原脱羧酶作为中药特定成分的潜在靶标：虚拟筛选和分子动力学研究。
PLoS One. 2012;7(11):e50087. doi: 10.1371/journal.pone.0050087. Epub 2012 Nov 29.
2
Structure and function of enzymes in heme biosynthesis.血红素生物合成中酶的结构与功能。
Protein Sci. 2010 Jun;19(6):1137-61. doi: 10.1002/pro.405.
3
Formation of N-methyl protoporphyrin in chemically-induced protoporphyria. Studies with a novel porphyrogenic agent.
Arch Toxicol. 1993;67(3):179-85. doi: 10.1007/BF01973305.
4
Purification and properties of the uroporphyrinogen decarboxylase from Rhodobacter sphaeroides.球形红杆菌尿卟啉原脱羧酶的纯化及性质
Biochem J. 1993 Aug 1;293 ( Pt 3)(Pt 3):703-12. doi: 10.1042/bj2930703.
5
Drug-induced conversion of liver haem into modified porphyrins. Evidence for two classes of products.药物诱导肝脏血红素转化为修饰卟啉。两类产物的证据。
Biochem J. 1980 Apr 1;187(1):285-8. doi: 10.1042/bj1870285.
6
Investigations of rat liver uroporphyrinogen decarboxylase. Comparisons of porphyrinogens I and III as substrates and the inhibition by porphyrins.大鼠肝脏尿卟啉原脱羧酶的研究。卟啉原I和III作为底物的比较以及卟啉的抑制作用。
Biochem J. 1981 Apr 1;195(1):241-50. doi: 10.1042/bj1950241.
7
Formation of N-alkylated protoporphyrin IX in the livers of mice after diethylnitrosamine treatment.二乙基亚硝胺处理后小鼠肝脏中N-烷基化原卟啉IX的形成。
Biochem J. 1983 Jun 15;212(3):599-608. doi: 10.1042/bj2120599.
8
N-alkylation of the haem moiety of cytochrome P-450 caused by substituted dihydropyridines. Preferential attack of different pyrrole nitrogen atoms after induction of various cytochrome P-450 isoenzymes.取代二氢吡啶引起的细胞色素P-450血红素部分的N-烷基化。诱导各种细胞色素P-450同工酶后不同吡咯氮原子的优先攻击。
Biochem J. 1983 May 1;211(2):455-61. doi: 10.1042/bj2110455.
9
Purification of uroporphyrinogen decarboxylase from human erythrocytes. Immunochemical evidence for a single protein with decarboxylase activity in human erythrocytes and liver.人红细胞中尿卟啉原脱羧酶的纯化。人红细胞和肝脏中具有脱羧酶活性的单一蛋白质的免疫化学证据。
Biochem J. 1983 Oct 1;215(1):45-55. doi: 10.1042/bj2150045.
10
Synergism of iron and hexachlorobenzene inhibits hepatic uroporphyrinogen decarboxylase in inbred mice.铁与六氯苯的协同作用抑制近交系小鼠肝脏中的尿卟啉原脱羧酶。
Biochem J. 1983 Sep 15;214(3):909-13. doi: 10.1042/bj2140909.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
A qualitative and quantitative study of the separation of uroporphyrin octamethyl esters I and III by dioxan chromatography.通过二氧六环色谱法对尿卟啉八甲基酯I和III进行分离的定性和定量研究。
J Chromatogr. 1963 Feb;10:141-57. doi: 10.1016/s0021-9673(01)92287-3.
3
Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase.红细胞中的卟啉生物合成。III. 尿卟啉原及其脱羧酶。
J Biol Chem. 1958 Jun;232(2):1141-62.
4
Transformation of porphobilinogen into porphyrins by preparations from human erythrocytes.人红细胞制剂将胆色素原转化为卟啉的过程。
Biochem J. 1964 Apr;91(1):64-73. doi: 10.1042/bj0910064.
5
Uroporphyrinogen decarboxylase from mouse spleen.来自小鼠脾脏的尿卟啉原脱羧酶。
Biochim Biophys Acta. 1971 Feb 23;230(2):330-41. doi: 10.1016/0304-4165(71)90220-0.
6
The pattern of porphyrin isomer accumulation and excretion in symptomatic porphyria.有症状的卟啉症中卟啉异构体积累和排泄的模式。
Clin Sci. 1970 Aug;39(2):147-58. doi: 10.1042/cs0390147.
7
Porphyrin biosynthesis. X. Porphyrinogen carboxy-lyase from avian erythrocytes: further properties.卟啉生物合成。X. 来自禽红细胞的卟啉原羧基裂解酶：更多特性。
Biochim Biophys Acta. 1973 May 5;309(1):203-10. doi: 10.1016/0005-2744(73)90332-x.
8
Decarboxylation of uroporphyrin by heating at atmospheric pressure.在大气压下加热使尿卟啉脱羧。
Biochem J. 1975 May;147(2):249-51. doi: 10.1042/bj1470249.
9
The role of iron in the pathogenesis of porphyria cutanea tarda. II. Inhibition of uroporphyrinogen decarboxylase.铁在迟发性皮肤卟啉症发病机制中的作用。II. 对尿卟啉原脱羧酶的抑制作用
J Clin Invest. 1975 Sep;56(3):661-7. doi: 10.1172/JCI108136.
10
The effect of the porphyrogenic compound, hexachlorobenzene, on the activity of hepatic uroporphyrinogen decarboxylase in the rat.致卟啉化合物六氯苯对大鼠肝脏尿卟啉原脱羧酶活性的影响。
Clin Sci Mol Med. 1976 Jul;51(1):71-80. doi: 10.1042/cs0510071.
Zotero 插件