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临床HIV治疗中单片与多片抗逆转录病毒治疗方案的比较效果

Comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical HIV practice.

作者信息

Drozd Daniel R, Saag Michael S, Westfall Andrew O, Mathews William Chris, Haubrich Richard, Boswell Stephen L, Cole Stephen R, Porter Donna, Kitahata Mari M, Juday Timothy, Rosenblatt Lisa

机构信息

Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA Division of Infectious Diseases Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL Department of Medicine, University of California San Diego, San Diego Gilead Sciences, Foster City, CA Fenway Health Center, Harvard Medical School, Boston, MA Department of Epidemiology, University of North Carolina, Chapel Hill, NC Bristol-Myers Squibb, Princeton, NJ.

出版信息

Medicine (Baltimore). 2017 Apr;96(14):e6275. doi: 10.1097/MD.0000000000006275.

DOI:10.1097/MD.0000000000006275
PMID:28383402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5411186/
Abstract

We determined risk of virologic failure (VF) in individuals initiating tenofovir/emtricitabine/efavirenz as single versus multiple tablet regimens (MTR). We found no significant difference in the risk of VF, though did observe a trend toward more VF and M184 V mutations among persons initiating MTR. Temporal trends in care may have confounded results.

摘要

我们确定了开始使用替诺福韦/恩曲他滨/依非韦伦单一片剂方案（STR）与多片剂型方案（MTR）的个体发生病毒学失败（VF）的风险。我们发现VF风险无显著差异，不过确实观察到开始使用MTR的人群中VF和M184V突变有增加的趋势。治疗的时间趋势可能混淆了结果。

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Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel.成人 HIV 感染的抗逆转录病毒治疗：国际艾滋病协会-美国小组 2010 年的建议。
JAMA. 2010 Jul 21;304(3):321-33. doi: 10.1001/jama.2010.1004.
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