Merker Andrew, Badowski Melissa, Chiampas Thomas, Pérez Sarah E, Patel Mahesh, Young Jeremy, Werner Ryan
1 Department of Pharmacy Practice, Midwestern University, Downers Grove, IL, USA.
2 Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
J Correct Health Care. 2018 Jan;24(1):52-61. doi: 10.1177/1078345817745334. Epub 2017 Dec 14.
Minimal information is available regarding antiretroviral prescribing patterns and outcomes for HIV patients in correctional systems. This study analyzes single- (STR) and multiple- (MTR) tablet regimen effectiveness in patients receiving HIV telemedicine care through the Illinois Department of Corrections (IDOC). This study involves a retrospective review of HIV-positive adult patients in IDOC on either an STR (efavirenz, rilpivirine, elvitegravir based) or an MTR (emtricitabine/tenofovir with atazanavir/ritonavir, darunavir/ritonavir, or raltegravir). No significant differences in virologic suppression were seen between groups at baseline, weeks 24, 48, 96, and last clinic visit. Similar proportions of patient-reported adverse effects, self-reported adherence, and discontinuation rates were found in both groups. With similar rates of viral suppression, tolerability, adherence, and discontinuation, administering MTR in the incarcerated population is a viable alternative to STR.
关于惩教系统中艾滋病毒患者的抗逆转录病毒药物处方模式和治疗结果的信息极少。本研究分析了通过伊利诺伊州惩教部（IDOC）接受艾滋病毒远程医疗护理的患者中单片（STR）和多片（MTR）方案的有效性。本研究涉及对IDOC中接受基于STR（依非韦伦、利匹韦林、埃替拉韦）或MTR（恩曲他滨/替诺福韦联合阿扎那韦/利托那韦、达芦那韦/利托那韦或拉替拉韦）治疗的艾滋病毒阳性成年患者进行回顾性研究。在基线、第24周、第48周、第96周和最后一次门诊就诊时，两组之间在病毒学抑制方面未观察到显著差异。两组患者报告的不良反应、自我报告的依从性和停药率比例相似。由于病毒抑制率、耐受性、依从性和停药率相似，在被监禁人群中使用MTR是STR的一个可行替代方案。
