Zhang Jinhua, Sun Xudong, Wang Jiemin, Zhang Fuhua, Li Xiaohua, Han Jian
Department of Gastroenterology, Second Hospital of Gansu Province, Lanzhou, China.
Department of Medicine, School of Second Clinical Medicine, Northwest University for Nationalities, Lanzhou, China.
PLoS One. 2017 Apr 6;12(4):e0175052. doi: 10.1371/journal.pone.0175052. eCollection 2017.
The aim of this study was to clarify the association of IL-1RN variable number of tandem repeat (VNTR) polymorphism and H. pylori infection. We performed a meta-analysis of studies retrieved by systematic searches of Pubmed, Embase and the Cochrane Library. Data were analyzed with STATA 13.1 using pooled odds ratios (ORs) with 95% confidence intervals (CIs). A total of 18 studies were included in our meta-analysis, and IL-1RN VNTR was found to be significantly associated with H. pylori infection in the comparisons of 22+2L vs. LL (OR = 1.17, 95% CI = 1.02-1.33) and 2 allele vs. L allele (OR = 1.18, 95% CI = 1.00-1.40). Stratified analyses on study designs and ethnicities were also conducted. IL-1RN VNTR was positively correlated with H. pylori infection in Asian subgroup and Hospital-Based subgroup (i.e., study samples obtained from hospital inpatients). In conclusion, our study demonstrated that IL-1RN VNTR polymorphism might increase the risk of H. pylori infection, especially in Asians.
本研究的目的是阐明白细胞介素-1受体拮抗剂（IL-1RN）可变数目串联重复序列（VNTR）多态性与幽门螺杆菌感染之间的关联。我们对通过系统检索PubMed、Embase和Cochrane图书馆获得的研究进行了荟萃分析。使用STATA 13.1软件，采用合并比值比（OR）及95%置信区间（CI）对数据进行分析。我们的荟萃分析共纳入18项研究，在22+2L与LL的比较中（OR = 1.17，95% CI = 1.02 - 1.33）以及2等位基因与L等位基因的比较中（OR = 1.18，95% CI = 1.00 - 1.40），发现IL-1RN VNTR与幽门螺杆菌感染显著相关。还对研究设计和种族进行了分层分析。在亚洲亚组和基于医院的亚组（即从医院住院患者获得的研究样本）中，IL-1RN VNTR与幽门螺杆菌感染呈正相关。总之，我们的研究表明，IL-1RN VNTR多态性可能会增加幽门螺杆菌感染的风险，尤其是在亚洲人中。
