蛋白质分泌缺陷对大肠杆菌secA基因的调控：secA、secB、secD和secY突变体的分析
Regulation of the Escherichia coli secA gene by protein secretion defects: analysis of secA, secB, secD, and secY mutants.
作者信息
Rollo E E, Oliver D B
机构信息
Department of Microbiology, State University of New York, Stony Brook 11794-8621.
出版信息
J Bacteriol. 1988 Jul;170(7):3281-2. doi: 10.1128/jb.170.7.3281-3282.1988.
Abstract
SecA protein synthesis levels were elevated 10- to 20-fold when protein secretion was blocked in secA, secD, and secY mutants or in a malE-lacZ fusion-containing strain but not in a secB null mutant. An active secB gene product was not required to derepress secA, since SecA levels were elevated during protein export blocks in secB secY and secB malE-lacZ double mutants.
摘要
当secA、secD和secY突变体或含有malE-lacZ融合基因的菌株中蛋白质分泌被阻断时，SecA蛋白合成水平提高了10至20倍，但在secB缺失突变体中未出现这种情况。解除对secA的抑制不需要有活性的secB基因产物，因为在secB secY和secB malE-lacZ双突变体的蛋白质输出阻断过程中，SecA水平升高。
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E. coli mutant pleiotropically defective in the export of secreted proteins.大肠杆菌突变体在分泌蛋白输出方面存在多效性缺陷。
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