Crane Jennine M, Randall Linda L
Department of Biochemistry, University of Missouri, Columbia, MO 65201.
EcoSal Plus. 2017 Nov;7(2). doi: 10.1128/ecosalplus.ESP-0002-2017.
In , proteins found in the periplasm or the outer membrane are exported from the cytoplasm by the general secretory, Sec, system before they acquire stably folded structure. This dynamic process involves intricate interactions among cytoplasmic and membrane proteins, both peripheral and integral, as well as lipids. , both ATP hydrolysis and proton motive force are required. Here, we review the Sec system from the inception of the field through early 2016, including biochemical, genetic, and structural data.
在周质或外膜中发现的蛋白质在获得稳定折叠结构之前，通过一般分泌（Sec）系统从细胞质中输出。这个动态过程涉及细胞质和膜蛋白（包括外周蛋白和整合蛋白）以及脂质之间复杂的相互作用。此外，ATP水解和质子动力都必不可少。在这里，我们回顾了从该领域创立到2016年初的Sec系统，包括生化、遗传和结构数据。
