Rajagopal Lavanya, Ganapathy Shivashekar, Arunachalam Sundaram, Raja Veena, Ramraj Balaji
Assistant Professor, Department of Pathology, SRM Medical College Hospital and Research Centre , Chennai, Tamilnadu, India .
Professor and Head, Department of Pathology, SRM Medical College Hospital and Research Centre , Chennai, Tamilnadu, India .
J Clin Diagn Res. 2017 Feb;11(2):EC13-EC15. doi: 10.7860/JCDR/2017/25183.9464. Epub 2017 Feb 1.
Anaemia has a high prevalence having great impact worldwide and potentially contributing to the pathogenesis of various chronic diseases. Approximately 1/3 of patients with anaemia have iron deficiency. American Diabetes Association (ADA) has affirmed Glycated Haemoglobin (HbA1C) ≥ 6.5% as a diagnostic criterion for Diabetes Mellitus (DM). Variation of HbA1C in Iron Deficiency Anaemia (IDA) has clashing results.
To decide the impact of IDA on HbA1C levels among non diabetics. To assess and analyse the variation of HbA1C according to the degree of anaemia (mild, moderate and severe).
This cross-sectional study was carried out in SRM Medical College Hospital and Research Centre, Chennai, Tamil Nadu from February 2016 to October 2016 and approved by our Institutional Ethical Committee. Totally 150 non diabetics (75 with IDA and 75 without IDA) were included in this study. Medical history was recorded and HbA1C, Haemoglobin (Hb), Haematocrit (Hct), red cell indices, serum iron, ferritin and Fasting Plasma Glucose (FPG) were tested.
The IDA patients in this study had a mean HbA1C (6.84±0.07%) which was higher than the non anaemic group (5.12±0.04%) and this difference was statistically significant (p< 0.05). HbA1C level was increased when severity of anaemia worsened. Also, noteworthy statistical significance was observed between no anaemia, mild, moderate and severe anaemia (p< 0.05).
In this study, we observed a positive correlation between IDA and elevated HbA1C level in non-diabetic population.
贫血在全球范围内具有很高的患病率，影响巨大，并可能导致各种慢性疾病的发病机制。大约三分之一的贫血患者存在缺铁情况。美国糖尿病协会（ADA）已确认糖化血红蛋白（HbA1C）≥6.5%作为糖尿病（DM）的诊断标准。缺铁性贫血（IDA）患者中HbA1C的变化结果相互矛盾。
确定IDA对非糖尿病患者HbA1C水平的影响。根据贫血程度（轻度、中度和重度）评估和分析HbA1C的变化。
本横断面研究于2016年2月至2016年10月在泰米尔纳德邦金奈的SRM医学院医院和研究中心进行，并获得了我们机构伦理委员会的批准。本研究共纳入150名非糖尿病患者（75名IDA患者和75名非IDA患者）。记录病史并检测HbA1C、血红蛋白（Hb）、血细胞比容（Hct）、红细胞指数、血清铁、铁蛋白和空腹血糖（FPG）。
本研究中IDA患者的平均HbA1C（6.84±0.07%）高于非贫血组（5.12±0.04%），且差异具有统计学意义（p<0.05）。贫血严重程度加重时，HbA1C水平升高。此外，在无贫血、轻度、中度和重度贫血之间观察到显著的统计学意义（p<0.05）。
在本研究中，我们观察到非糖尿病人群中IDA与HbA1C水平升高之间存在正相关。
