Guo Wenjia, Zhou Qi, Jia Yanan, Xu Jiancheng
Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, Jilin, China (mainland).
Department of Pediatrics, First Hospital of Jilin University, Changchun, Jilin, China (mainland).
Med Sci Monit. 2019 Nov 7;25:8371-8378. doi: 10.12659/MSM.916719.
Worldwide, the prevalence of diabetes remains high. Studies have shown that iron deficiency anemia (IDA) is associated with increased levels of glycated hemoglobin A1c (HbA1c), but the mechanism remains unclear. Hematological changes, iron metabolism, study methodology, and other factors could affect the results of diagnostic investigations, leading to false results. Red blood cell turnover in the bone marrow and the quality and heterogeneity of erythrocytes may influence the rate of hemoglobin glycation. By changing the structure of hemoglobin and inducing peroxidation, iron deficiency accelerates glycation. This review aims to discuss the possible causes of the association between increased levels of HbA1c and IDA.
在全球范围内，糖尿病的患病率仍然很高。研究表明，缺铁性贫血（IDA）与糖化血红蛋白A1c（HbA1c）水平升高有关，但其机制尚不清楚。血液学变化、铁代谢、研究方法及其他因素可能会影响诊断检查结果，导致出现错误结果。骨髓中的红细胞周转率以及红细胞的质量和异质性可能会影响血红蛋白糖化的速率。缺铁通过改变血红蛋白的结构并诱导过氧化反应，加速糖化过程。本综述旨在探讨HbA1c水平升高与IDA之间关联的可能原因。
