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一位老年女性患者肺镰刀菌病的意外证据转变——病例报告

A Fortuitous Turn of Evidence in an Elderly Female - A Case of Pulmonary Fusariosis.

作者信息

Sreeram Saraswathy, Lobo Flora Dorothy, Acharya Vishak, Saralaya Vishwas

机构信息

Assistant Professor, Department of Pathology, Manipal University , Mangaluru, Karnataka, India .

Professor, Department of Pathology, Manipal University , Mangaluru, Karnataka, India .

出版信息

J Clin Diagn Res. 2017 Feb;11(2):ED04-ED05. doi: 10.7860/JCDR/2017/24736.9191. Epub 2017 Feb 1.

Abstract

Pulmonary mycosis is seen infrequently in our country. It is more common in the immunocompromised. The infections caused by less known species like have been found to be increasing in incidence in other parts of the world. We hereby report its occurrence in a 79-year-old, non-immunocompromised female who presented with pyrexia of unknown origin. Her Alanine Phosphatase (ALP) and Lactate Dehydrogenase (LHD) levels were raised. CT scan showed interstitial thickening in subpleural aspect of lungs and multiple enlarged lymph nodes in mediastinum. Liver showed multiple hypodense lesions. Metastasis was suspected for which Fine Needle Aspiration Cytology (FNAC) of liver was done which showed foci of regenerative hepatocytes with desmoplastic stromal tissue fragments and negative for tumour. Her Alpha Fetoprotein (AFP) was normal. The bronchial tree cytology showed endobronchial cells, dust-laden macrophages and chronic inflammatory cells along with fungi on Pap smear studies. This was confirmed by culture that grew species after one week of incubation. The acutely branching septate hyphae of species are identical to those of In a patient who has a disseminated infection with a septate fungus, growth in culture is important to identify the specific organism and subsequently treatment with appropriate antifungals. In cases like ours, where the infection simulates malignancy, it is even more important to make the correct diagnosis to give the appropriate treatment.

摘要

肺真菌病在我国并不常见。在免疫功能低下者中更为常见。在世界其他地区,由一些不太知名的菌种引起的感染发病率一直在上升。我们在此报告一名79岁、免疫功能正常的女性出现不明原因发热的病例。她的碱性磷酸酶(ALP)和乳酸脱氢酶(LHD)水平升高。CT扫描显示肺胸膜下间质增厚,纵隔内多个淋巴结肿大。肝脏显示多个低密度病变。怀疑有转移,因此对肝脏进行了细针穿刺细胞学检查(FNAC),结果显示有再生肝细胞灶,伴有促纤维组织增生性间质组织碎片,肿瘤检查为阴性。她的甲胎蛋白(AFP)正常。支气管树细胞学检查显示,巴氏涂片研究中可见支气管内细胞、载尘巨噬细胞和慢性炎症细胞以及真菌。培养证实,培养一周后长出了 菌种。 菌种的急性分支分隔菌丝与 菌种的菌丝相同。在一名患有播散性分隔真菌感染的患者中,培养生长对于识别特定病原体以及随后使用适当的抗真菌药物进行治疗非常重要。在像我们这样的病例中,感染类似恶性肿瘤,做出正确诊断以给予适当治疗更为重要。

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