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Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma.使用化疗和mTOR抑制联合羟氯喹进行双重自噬刺激以调节复发或难治性多发性骨髓瘤患者的自噬
Haematologica. 2017 Jul;102(7):e261-e265. doi: 10.3324/haematol.2016.162321. Epub 2017 Apr 6.
2
Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma.自噬与蛋白酶体联合抑制：羟氯喹啉和硼替佐米对复发/难治性骨髓瘤患者的1期试验
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Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.羟氯喹增强卡非佐米对骨髓瘤细胞的毒性。
Oncotarget. 2016 Oct 25;7(43):70845-70856. doi: 10.18632/oncotarget.12226.
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Immunohistochemical Expression of mTOR in Multiple Myeloma: Retrospective Analysis of 31 Cases, a Clinicopathological Study.mTOR在多发性骨髓瘤中的免疫组化表达：31例回顾性分析，一项临床病理研究
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Clarithromycin attenuates autophagy in myeloma cells.克拉霉素可减弱骨髓瘤细胞中的自噬作用。
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Knockdown of DEPTOR induces apoptosis, increases chemosensitivity to doxorubicin and suppresses autophagy in RPMI-8226 human multiple myeloma cells in vitro.敲低 DEPTOR 可诱导 RPMI-8226 人多发性骨髓瘤细胞凋亡，增加多柔比星的化疗敏感性，并抑制自噬。
Int J Mol Med. 2013 May;31(5):1127-34. doi: 10.3892/ijmm.2013.1299. Epub 2013 Mar 12.

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NVP-BEZ235-induced autophagy as a potential therapeutic approach for multiple myeloma.NVP-BEZ235诱导的自噬作为多发性骨髓瘤的一种潜在治疗方法。
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The multifaceted role of autophagy in cancer and the microenvironment.自噬在癌症和微环境中的多效性作用。
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本文引用的文献

1
A comparison of salvage infusional chemotherapy regimens for recurrent/refractory multiple myeloma.比较挽救性输注化疗方案治疗复发性/难治性多发性骨髓瘤。
Cancer. 2015 Oct 15;121(20):3622-30. doi: 10.1002/cncr.29533. Epub 2015 Jul 6.
2
Emerging strategies to effectively target autophagy in cancer.有效靶向癌症自噬的新兴策略。
Oncogene. 2016 Jan 7;35(1):1-11. doi: 10.1038/onc.2015.99. Epub 2015 Apr 20.
3
Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma.联合抑制哺乳动物雷帕霉素靶蛋白（mTOR）和自噬：羟氯喹和替西罗莫司治疗晚期实体瘤和黑色素瘤患者的I期试验
Autophagy. 2014 Aug;10(8):1391-402. doi: 10.4161/auto.29119. Epub 2014 May 20.
4
Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma.自噬与蛋白酶体联合抑制：羟氯喹啉和硼替佐米对复发/难治性骨髓瘤患者的1期试验
Autophagy. 2014 Aug;10(8):1380-90. doi: 10.4161/auto.29264. Epub 2014 May 20.
5
Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation.Pim2 通过调节 TSC2 磷酸化来维持多发性骨髓瘤细胞的生长。
Blood. 2013 Aug 29;122(9):1610-20. doi: 10.1182/blood-2013-01-481457. Epub 2013 Jul 1.
6
Deconvoluting the context-dependent role for autophagy in cancer.解析自噬在癌症中依赖于上下文的作用。
Nat Rev Cancer. 2012 Apr 26;12(6):401-10. doi: 10.1038/nrc3262.
7
Principles and current strategies for targeting autophagy for cancer treatment.靶向自噬治疗癌症的原则和当前策略。
Clin Cancer Res. 2011 Feb 15;17(4):654-66. doi: 10.1158/1078-0432.CCR-10-2634.
8
Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy.靶向自噬增强 DNA 损伤化疗的体外和体内抗骨髓瘤活性。
Clin Cancer Res. 2011 May 15;17(10):3248-58. doi: 10.1158/1078-0432.CCR-10-0890. Epub 2011 Feb 2.
9
Effect of autophagy on multiple myeloma cell viability.自噬对多发性骨髓瘤细胞活力的影响。
Mol Cancer Ther. 2009 Jul;8(7):1974-84. doi: 10.1158/1535-7163.MCT-08-1177. Epub 2009 Jun 9.
10
Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma.替西罗莫司用于复发或难治性多发性骨髓瘤患者的II期试验。
Leuk Res. 2009 Nov;33(11):1475-80. doi: 10.1016/j.leukres.2009.01.039. Epub 2009 Mar 3.

Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma.

作者信息

Scott Emma C, Maziarz Richard T, Spurgeon Stephen E, Medvedova Eva, Gajewski James, Reasor-Heard Shara, Park Byung, Kratz Anne, Thomas George V, Loriaux Marc, Cascio Michael, Podolak Jennifer, Gordon Miranda, Botelho Jennifer, Stadtmauer Edward, Amaravadi Ravi, Vogl Dan T

机构信息

The Department of Medicine and the Knight Cancer Institute at Oregon Health & Science University, the University of Pennsylvania, PN, USA

The Department of Medicine and the Knight Cancer Institute at Oregon Health & Science University, the University of Pennsylvania, PN, USA.

出版信息

Haematologica. 2017 Jul;102(7):e261-e265. doi: 10.3324/haematol.2016.162321. Epub 2017 Apr 6.

DOI:10.3324/haematol.2016.162321
PMID:28385778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5566051/
Abstract
摘要