自噬在转移中的多效功能。
The pleiotropic functions of autophagy in metastasis.
机构信息
Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143 USA.
Thoracic Oncology Program, Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94115 USA.
出版信息
J Cell Sci. 2021 Jan 22;134(2):jcs247056. doi: 10.1242/jcs.247056.
Autophagy is deregulated in many cancers and represents an attractive target for therapeutic intervention. However, the precise contributions of autophagy to metastatic progression, the principle cause of cancer-related mortality, is only now being uncovered. While autophagy promotes primary tumor growth, metabolic adaptation and resistance to therapy, recent studies have unexpectedly revealed that autophagy suppresses the proliferative outgrowth of disseminated tumor cells into overt and lethal macrometastases. These studies suggest autophagy plays unexpected and complex roles in the initiation and progression of metastases, which will undoubtedly impact therapeutic approaches for cancer treatment. Here, we discuss the intricacies of autophagy in metastatic progression, highlighting and integrating the pleiotropic roles of autophagy on diverse cell biological processes involved in metastasis.
自噬在许多癌症中失调，代表了治疗干预的一个有吸引力的靶点。然而，自噬对转移性进展的精确贡献，即癌症相关死亡的主要原因，直到现在才被揭示出来。虽然自噬促进了原发性肿瘤的生长、代谢适应和对治疗的抵抗，但最近的研究出人意料地揭示了自噬抑制了播散性肿瘤细胞增殖性生长为明显的和致命的巨转移。这些研究表明，自噬在转移的发生和进展中发挥了意想不到的复杂作用，这无疑将影响癌症治疗的治疗方法。在这里，我们讨论了自噬在转移性进展中的复杂性，强调并整合了自噬在涉及转移的各种细胞生物学过程中的多效性作用。
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