Laboratoire de Physique Statistique, Ecole Normale Supérieure, CNRS, Université Pierre et Marie Curie, Université Paris Diderot, 75005 Paris, France.
Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France.
Science. 2017 May 5;356(6337). doi: 10.1126/science.aai7407. Epub 2017 Apr 6.
The emergence of spatial patterns in developing multicellular organisms relies on positional cues and cell-cell communication. sensory organs have informed a paradigm in which these operate in two distinct steps: Prepattern factors drive localized proneural activity, then Notch-mediated lateral inhibition singles out neural precursors. Here we show that self-organization through Notch signaling also establishes the proneural stripes that resolve into rows of sensory bristles on the fly thorax. Patterning, initiated by a gradient of Delta ligand expression, progresses through inhibitory signaling between and within stripes. Thus, Notch signaling can support self-organized tissue patterning as a prepattern is transduced by cell-cell interactions into a refined arrangement of cellular fates.
多细胞生物中空间模式的出现依赖于位置线索和细胞间的通讯。 感觉器官提供了一个范例，其中这些操作分为两个不同的步骤：预模式因子驱动局部神经前体活性，然后 Notch 介导的侧向抑制将神经前体分离出来。 在这里，我们表明 Notch 信号转导的自组织也建立了神经条纹，这些条纹在果蝇胸部上解析为感觉刚毛的行。 通过 Delta 配体表达的梯度引发的模式形成，通过条纹之间和内部的抑制信号传递。 因此，Notch 信号可以支持自我组织的组织模式形成，因为前模式通过细胞间相互作用转导为细胞命运的精细排列。
