Beghelli Daniela, Isani Gloria, Roncada Paola, Andreani Giulia, Bistoni Onelia, Bertocchi Martina, Lupidi Giulio, Alunno Alessia
School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Italy.
Oxid Med Cell Longev. 2017;2017:7468064. doi: 10.1155/2017/7468064. Epub 2017 Mar 13.
(BS) is an important traditional medicinal plant that currently represents an interesting topic for pharmaceutical research since it possesses several pharmacological properties (e.g., anti-inflammatory, antimicrobial, and antitumour). The safety and versatility of this dietary supplement should allow for its use in numerous pathological conditions; however the quality of the extracts needs to be standardized to increase the clinical success rate resulting from its use. In the present study, different commercially available extracts were employed to compare their AKBA content and in vitro antioxidant power. Furthermore, their ability to modulate the immune system regulatory properties was investigated. Our results showed that the AKBA content varied from 3.83 ± 0.10 to 0.03 ± 0.004%, with one sample in which it was not detectable. The highest antioxidant power and phenolic content were shown by the same extract, which also exhibited the highest AKBA concentration. Finally, the BS extracts showed the ability to influence the regulatory and effector T-cell compartments. Our results suggest that frankincense should be further investigated for its promising potentiality to modulate not only inflammation/oxidative stress but also immune dysregulation, but attention should be paid to the composition of the commercial extracts.
乳香是一种重要的传统药用植物，目前是药物研究的一个有趣课题，因为它具有多种药理特性（如抗炎、抗菌和抗肿瘤）。这种膳食补充剂的安全性和多功能性使其可用于多种病理状况；然而，提取物的质量需要标准化，以提高其使用的临床成功率。在本研究中，使用了不同的市售提取物来比较它们的乙酰基-11-酮基-β-乳香酸（AKBA）含量和体外抗氧化能力。此外，还研究了它们调节免疫系统调节特性的能力。我们的结果表明，AKBA含量在3.83±0.10%至0.03±0.004%之间变化，有一个样品中未检测到。同一种提取物显示出最高的抗氧化能力和酚类含量，其AKBA浓度也最高。最后，乳香提取物显示出影响调节性和效应性T细胞区室的能力。我们的结果表明，乳香因其不仅能调节炎症/氧化应激，还能调节免疫失调的潜在前景而应进一步研究，但应注意市售提取物的成分。
