青环酮A-E，源自深海真菌青霉菌F23-2的抗菌聚酮化合物。
Penicyclones A-E, Antibacterial Polyketides from the Deep-Sea-Derived Fungus Penicillium sp. F23-2.
作者信息
Guo Wenqiang, Zhang Zhenzhen, Zhu Tianjiao, Gu Qianqun, Li Dehai
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
出版信息
J Nat Prod. 2015 Nov 25;78(11):2699-703. doi: 10.1021/acs.jnatprod.5b00655. Epub 2015 Nov 5.
Five new ambuic acid analogues, penicyclones A-E (1-5), were isolated from the extract of the deep-sea-derived fungus Penicillium sp. F23-2. The structures including the absolute configurations were established by interpretation of NMR and MS data, as well as the application of ECD, X-ray crystallography, and a chemical conversion, as well as the TDDFT-ECD calculations. Penicyclones A-E (1-5) exhibited antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus with MIC values ranging from 0.3 to 1.0 μg/mL.
从深海来源的青霉菌株Penicillium sp. F23-2的提取物中分离出了5种新的ambuic酸类似物，即青霉环素A-E（1-5）。通过对核磁共振（NMR）和质谱（MS）数据的解析，以及电子圆二色谱（ECD）、X射线晶体学、化学转化的应用，还有含时密度泛函理论电子圆二色谱（TDDFT-ECD）计算，确定了其结构包括绝对构型。青霉环素A-E（1-5）对革兰氏阳性菌金黄色葡萄球菌表现出抗菌活性，最低抑菌浓度（MIC）值在0.3至1.0μg/mL之间。
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