Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand.
Addiction. 2017 Sep;112(9):1629-1637. doi: 10.1111/add.13838. Epub 2017 May 12.
There has been a great deal of evidence showing that high novelty seeking (NS) is a risk factor for the development of substance use disorders (SUDs). However, the possible causal role of NS in SUDs is unconfirmed. The aim of this study was to examine the associations between NS at age 16 and SUDs from ages 18 to 35 years, net of a series of covariate factors.
Longitudinal study of a birth cohort.
Christchurch, New Zealand.
General community sample with sample sizes ranging from n = 1011 (age 21) to n = 962 (age 35).
The Composite International Diagnostic Interview was used to derive DSM-IV diagnoses of alcohol, nicotine, cannabis and other illicit SUDs at four time intervals from ages 18 to 35. NS was measured at age 16 using the Tridimensional Personality Questionnaire.
An increase in NS was associated with increases in the prevalence of all four SUDs at age 18-35. Following adjustment for a broad range of covariate factors, estimated effect sizes (odds ratios) were reducing in magnitude, but remained moderate to large. Adjusted odds ratios of SUDs for the highest NS quartile compared to with the lowest were 2.0 [95% confidence interval (CI) = 1.5, 2.7] for alcohol; 1.8 (95% CI = 1.3, 2.7) for nicotine; 3.6 (95% CI = 2.4, 5.6) for cannabis and 5.1 (95% CI = 2.9, 9.2) for other illicit substances.
The association between high novelty seeking and substance use disorders is not explained by common underlying individual factors and environmental exposures. This is consistent with the view that novelty seeking may play a causal role in the development of substance use disorders.
大量证据表明，高新奇寻求（NS）是物质使用障碍（SUD）发展的一个风险因素。然而，NS 在 SUD 中的可能因果作用尚未得到证实。本研究的目的是检验 16 岁时的 NS 与 18 至 35 岁时的 SUD 之间的关联，这些关联在一系列协变量因素之外。
一项出生队列的纵向研究。
新西兰克赖斯特彻奇。
从 n=1011（21 岁）到 n=962（35 岁）不等的一般社区样本。
使用复合国际诊断访谈从 18 至 35 岁的四个时间间隔中得出 DSM-IV 酒精、尼古丁、大麻和其他非法物质使用障碍的诊断。在 16 岁时使用三维人格问卷测量 NS。
NS 的增加与 18-35 岁期间所有四种 SUD 的患病率增加有关。在调整了广泛的协变量因素后，估计的效应大小（优势比）虽然有所减小，但仍然处于中等至较大的水平。与最低 NS 四分位相比，最高 NS 四分位的 SUD 调整后的优势比为 2.0 [95%置信区间（CI）=1.5, 2.7] 用于酒精；1.8（95%CI=1.3, 2.7）用于尼古丁；3.6（95%CI=2.4, 5.6）用于大麻和 5.1（95%CI=2.9, 9.2）用于其他非法物质。
高新奇寻求与物质使用障碍之间的关联不能用共同的潜在个体因素和环境暴露来解释。这与新奇寻求可能在物质使用障碍的发展中起因果作用的观点一致。
