Woo Bok Hee, Kim Da Jeong, Choi Jeom Il, Kim Sung Jo, Park Bong Soo, Song Jae Min, Lee Ji Hye, Park Hae Ryoun
Department of Oral Pathology & BK21 PLUS Project, School of Dentistry, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.
Department of Periodontology, School of Dentistry, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.
Oncotarget. 2017 Jul 18;8(29):46981-46992. doi: 10.18632/oncotarget.16550.
Major obstacles to improving the prognosis of patients with oral squamous cell carcinoma (OSCC) are the acquisition of resistance to chemotherapeutic agents and development of metastases. Recently, inflammatory signals are suggested to be one of the most important factors in modulating chemoresistance and establishing metastatic lesions. In addition, epidemiological studies have demonstrated that periodontitis, the most common chronic inflammatory condition of the oral cavity, is closely associated with oral cancer. However, a correlation between chronic periodontitis and chemoresistance/metastasis has not been well established. Herein, we will present our study on whether sustained infection with Porphyromonas gingivalis, a major pathogen of chronic periodontitis, could modify the response of OSCC cells to chemotherapeutic agents and their metastatic capability in vivo. Tumor xenografts composed of P. gingivalis-infected OSCC cells demonstrated a higher resistance to Taxol through Notch1 activation, as compared with uninfected cells. Furthermore, P. gingivalis-infected OSCC cells formed more metastatic foci in the lung than uninfected cells.
口腔鳞状细胞癌（OSCC）患者预后改善的主要障碍是对化疗药物产生耐药性以及发生转移。最近，炎症信号被认为是调节化疗耐药性和形成转移病灶的最重要因素之一。此外，流行病学研究表明，牙周炎作为口腔最常见的慢性炎症性疾病，与口腔癌密切相关。然而，慢性牙周炎与化疗耐药性/转移之间的相关性尚未完全确立。在此，我们将展示关于慢性牙周炎的主要病原体牙龈卟啉单胞菌的持续感染是否会改变OSCC细胞对化疗药物的反应及其体内转移能力的研究。与未感染细胞相比，由牙龈卟啉单胞菌感染的OSCC细胞组成的肿瘤异种移植通过Notch1激活对紫杉醇表现出更高的耐药性。此外，牙龈卟啉单胞菌感染的OSCC细胞在肺部形成的转移灶比未感染细胞更多。
