口腔厌氧菌与胰腺癌之间的关联
The Association Between Oral Anaerobic Bacteria and Pancreatic Cancer.
作者信息
Ogrendik Mesut
机构信息
Department of Physical Medicine and Rehabilitation, Izmir Democracy University, Seyfi Demirsoy Training and Research Hospital, Buca, Izmir, Turkey. Email:
出版信息
World J Oncol. 2023 Jun;14(3):174-177. doi: 10.14740/wjon1596. Epub 2023 Jun 11.
Abstract
Reports have shown increased positive correlations with the salivary microbiota and pancreatic carcinogenesis. A European study showed that high levels of were correlated with periodontium damage and were associated with a risk of pancreatic cancer (two-fold). A recent study, using oral mouthwash samples (n = 361 with pancreatic adenocarcinoma), determined that the presence of and along with and were a risk factor for pancreatic cancer. The link between pancreatic cancer and periodontitis has been documented. Interestingly, periodontitis presents with inflammation and microbial dysbiosis, both of which have been characterized in pancreatic cancer. This review highlights multiple roles in which oral anaerobic bacteria can spread to the pancreas and contribute to pancreatic cancer.
摘要
报告显示，唾液微生物群与胰腺癌发生之间的正相关性增加。一项欧洲研究表明，高水平的[具体物质未给出]与牙周组织损伤相关，并与胰腺癌风险（两倍）相关。最近一项研究，使用口腔漱口水样本（361例胰腺腺癌患者），确定[具体物质未给出]以及[具体物质未给出]的存在是胰腺癌的一个风险因素。胰腺癌与牙周炎之间的联系已有文献记载。有趣的是，牙周炎表现为炎症和微生物群落失调，这两者在胰腺癌中都有特征。本综述强调了口腔厌氧菌可扩散至胰腺并促成胰腺癌的多种作用。
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本文引用的文献
1
Citrullination in Cancer.瓜氨酸化在癌症中的作用。
Cancer Res. 2019 Apr 1;79(7):1274-1284. doi: 10.1158/0008-5472.CAN-18-2797. Epub 2019 Mar 20.
2
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World J Oncol. 2019 Feb;10(1):10-27. doi: 10.14740/wjon1166. Epub 2019 Feb 26.
3
Citrullination as a plausible link to periodontitis, rheumatoid arthritis, atherosclerosis and Alzheimer's disease.瓜氨酸化作为牙周炎、类风湿性关节炎、动脉粥样硬化和阿尔茨海默病之间可能的联系。
J Oral Microbiol. 2018 Jun 22;10(1):1487742. doi: 10.1080/20002297.2018.1487742. eCollection 2018.
4
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Nat Rev Rheumatol. 2017 Oct;13(10):606-620. doi: 10.1038/nrrheum.2017.132. Epub 2017 Aug 24.
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8
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9
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10
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