Zhang Wei-Long, Yu Lian-Pin, Zhou Wei, Wang Xue, Du Juan
Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
School of Stomatology, Shandong First Medical University, Jinan, China.
Arch Microbiol. 2025 May 12;207(6):143. doi: 10.1007/s00203-025-04342-y.
Oral lichen planus (OLP) is a prevalent T-cell mediated inflammatory-immune disease with uncertain etiology. Recently, there is emerging evidence suggesting that oral bacteria may exert a prominent role in the onset and development of OLP. They might promote the initiation and progression of OLP by disrupting the oral epithelia, invading the lamina propria, stimulating pro-inflammatory cytokines production and inducing immune dysfunction. In this review, we will focus on the possible mechanisms of oral bacteria contributing to occurrence and development of OLP, and provide new insights into the bacteria-related diagnosis, prevention and treatment strategies for OLP.
口腔扁平苔藓（OLP）是一种常见的T细胞介导的炎症性免疫疾病，病因尚不明确。最近，越来越多的证据表明口腔细菌可能在OLP的发生和发展中发挥重要作用。它们可能通过破坏口腔上皮、侵入固有层、刺激促炎细胞因子产生和诱导免疫功能障碍来促进OLP的起始和进展。在这篇综述中，我们将聚焦于口腔细菌促成OLP发生和发展的可能机制，并为OLP的细菌相关诊断、预防和治疗策略提供新的见解。
