Silvestrini B
Istituto di Farmacologia e Farmacognosia, Universita' La Sapienza, Roma, Italia.
Psychopharmacology (Berl). 1988;95 Suppl:S1-2. doi: 10.1007/BF00172620.
Trazodone and tricyclics share similar activity towards the core symptoms of depression, whereas their effects on neurohumoral transmission tend to be opposite. This once again casts doubt upon the theories on depression postulated from the study of monoamine oxidase inhibitors and tricyclics. The effects of trazodone and tricyclics on the autonomic nervous system are also different, reflecting, respectively, the alpha-adrenergic blocking activity of the former and the muscarinic-anticholinergic and alpha-adrenergic stimulating properties of the latter. It is stressed that the autonomic changes that accompany depression to some extent overlap those produced by tricyclics, whereas they are generally relieved by trazodone. This drug, therefore, extends the previous limitations of antidepressant treatment.
曲唑酮和三环类药物对抑郁症的核心症状具有相似的作用，而它们对神经体液传递的影响却往往相反。这再次对从单胺氧化酶抑制剂和三环类药物研究中提出的抑郁症理论产生了怀疑。曲唑酮和三环类药物对自主神经系统的作用也不同，分别反映了前者的α-肾上腺素能阻断活性和后者的毒蕈碱-抗胆碱能及α-肾上腺素能刺激特性。需要强调的是，抑郁症伴随的自主神经变化在一定程度上与三环类药物产生的变化重叠，而这些变化通常会被曲唑酮缓解。因此，这种药物扩展了先前抗抑郁治疗的局限性。
