Price L H, Charney D S, Heninger G R
Psychopharmacology (Berl). 1986;89(1):38-44. doi: 10.1007/BF00175186.
Tricyclic antidepressant drugs reduce the sensitivity of alpha 2 adrenoceptors during long-term treatment. In the present study, the alpha 2 adrenergic agonist clonidine was administered to 11 depressed patients before and during treatment with the triazolopyridine antidepressant trazodone (TRZ). Clonidine's ability to decrease blood pressure (BP) and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), and to increase sedation and plasma growth hormone (GH), were measured. TRZ had little effect on these indices of pre- and postsynaptic alpha 2 receptor function, suggesting that the antidepressant properties of TRZ are not related to changes in alpha 2 adrenoceptor sensitivity.
三环类抗抑郁药在长期治疗期间会降低α2肾上腺素能受体的敏感性。在本研究中，对11名抑郁症患者在使用三唑吡啶类抗抑郁药曲唑酮（TRZ）治疗前及治疗期间给予α2肾上腺素能激动剂可乐定。测量了可乐定降低血压（BP）、去甲肾上腺素代谢产物3-甲氧基-4-羟基苯乙二醇（MHPG）的血浆水平、增加镇静作用和血浆生长激素（GH）的能力。TRZ对这些突触前和突触后α2受体功能指标影响很小，这表明TRZ的抗抑郁特性与α2肾上腺素能受体敏感性的变化无关。
