Silvestrini B
Neuropsychobiology. 1986;15 Suppl 1:2-9. doi: 10.1159/000118270.
The mental pain hypothesis used to develop trazodone is illustrated, together with its medical and methodological implications. Trazodone possesses a well documented antidepressant activity, which indirectly confirms the above hypothesis. It lacks the aminergic effects of other antidepressants and has a marked adrenolytic activity. Therefore it is potentially indicated in depressive states with adrenergic hyperactivation, such as during alcohol withdrawal. The methodological aspects of the approach taken for trazodone are also discussed, in the context of the strategies of psychopharmacological research.
阐述了用于研发曲唑酮的精神痛苦假说及其医学和方法学意义。曲唑酮具有充分记录的抗抑郁活性，这间接证实了上述假说。它缺乏其他抗抑郁药的胺能作用，且具有显著的抗肾上腺素能活性。因此，它可能适用于肾上腺素能过度激活的抑郁状态，如在酒精戒断期间。还在精神药理学研究策略的背景下讨论了曲唑酮所采用方法的方法学方面。
