孕产妇高血压疾病与早产儿视网膜病变的关联：一项系统评价和荟萃分析。
Association of maternal hypertensive disorders with retinopathy of prematurity: A systematic review and meta-analysis.
作者信息
Zhu TingTing, Zhang Li, Zhao FengYan, Qu Yi, Mu Dezhi
机构信息
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, Sichuan, China.
出版信息
PLoS One. 2017 Apr 7;12(4):e0175374. doi: 10.1371/journal.pone.0175374. eCollection 2017.
BACKGROUD
The role of maternal hypertensive disorders in pregnancy (HDP) in the development of retinopathy of prematurity (ROP) is unclear.
METHODS
Studies were retrieved through literature searches in PubMed, EMBASE, Web of Science and the Cochrane Library up to May 5, 2016 without language restrictions. Cohort or case-control studies that reported the association of maternal hypertensive disorders and retinopathy of prematurity were eligible. Either a fixed- or a random-effects model was used to calculate the overall combined risk estimates.
RESULTS
Thirteen cohort studies involving a total of 45082 individuals were included in the review. The pooled odds ratios of maternal hypertensive disorders in pregnancy for any stage and severe stages of ROP was 1.12 (95%CI: 0.90-1.40) and 0.80 (95%CI: 0.47-1.35), respectively. Sensitivity analyses confirmed that no single study qualitatively influenced the pooled OR. However, substantial heterogeneity and publication bias were observed in the meta-analysis.
CONCLUSIONS
Additional larger, prospective and well-adjusted studies are needed to determine the association between HDP and ROP, especially regarding the effects of different types of maternal hypertensive disorders in pregnancy on retinopathy of prematurity.
背景
孕期母亲高血压疾病（HDP）在早产儿视网膜病变（ROP）发展中的作用尚不清楚。
方法
通过检索PubMed、EMBASE、科学网和考克兰图书馆截至2016年5月5日的文献获取研究，无语言限制。报告母亲高血压疾病与早产儿视网膜病变关联的队列研究或病例对照研究符合条件。采用固定效应模型或随机效应模型计算总体合并风险估计值。
结果
该综述纳入了13项队列研究，共涉及45082名个体。孕期母亲高血压疾病在ROP任何阶段和严重阶段的合并比值比分别为1.12（95%置信区间：0.90 - 1.40）和0.80（95%置信区间：0.47 - 1.35）。敏感性分析证实，没有一项研究在质上影响合并后的比值比。然而，在荟萃分析中观察到显著的异质性和发表偏倚。
结论
需要更多更大规模、前瞻性且经过充分调整的研究来确定HDP与ROP之间的关联，特别是关于孕期不同类型母亲高血压疾病对早产儿视网膜病变的影响。
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