Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 34141, Republic of Korea.
Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 34141, Republic of Korea; Department of Biological Sciences, Korea Advanced Institute for Science and Technology, Daejeon 34141, Republic of Korea.
Curr Opin Neurobiol. 2017 Aug;45:45-50. doi: 10.1016/j.conb.2017.03.005. Epub 2017 Apr 6.
Synaptic adhesion molecules have been extensively studied for their contribution to the regulation of synapse development through trans-synaptic adhesions. However, accumulating evidence increasingly indicates that synaptic adhesion molecules are also involved in the regulation of excitatory synaptic transmission and plasticity, often through direct or close associations with excitatory neurotransmitter receptors. This review summarizes recent results supporting this emerging concept and underlying mechanisms, and addresses its implications.
突触黏附分子通过形成跨突触黏附在调节突触发育中起重要作用，这一点已得到广泛研究。然而，越来越多的证据表明，突触黏附分子也参与调节兴奋性突触传递和可塑性，通常通过与兴奋性神经递质受体直接或密切相关来实现。本综述总结了支持这一新兴概念及其潜在机制的最新研究结果，并探讨了其意义。
