加那利群岛慢性阻塞性肺疾病患者的心血管合并症（CCECAN研究）。

Cardiovascular comorbidity in patients with chronic obstructive pulmonary disease in the Canary Islands (CCECAN study).

作者信息

Figueira Gonçalves Juan Marco, Dorta Sánchez Rafael, Rodri Guez Pérez María Del Cristo, Viña Manrique Pedro, Díaz Pérez David, Guzmán Saenz Cristina, Palmero Tejera Juan Manuel, Pérez Rodríguez Alicia, Pérez Negrín Lorenzo

机构信息

Servicio de Neumología y Cirugía Torácica, Hospital Universitario Nuestra Señora de La Candelaria, Santa Cruz de Tenerife, España.

出版信息

Clin Investig Arterioscler. 2017 Jul-Aug;29(4):149-156. doi: 10.1016/j.arteri.2017.01.003. Epub 2017 Apr 5.

DOI:10.1016/j.arteri.2017.01.003

PMID:28390852

Abstract

INTRODUCTION

Numerous studies have shown a high prevalence of cardiovascular disease in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to analyse the prevalence of cardiovascular risk factors and comorbidity in a Canary Islands population diagnosed with COPD, and compared it with data from the general population.

PATIENTS AND METHODS

A cross-sectional study was carried out in 300 patients with COPD and 524 subjects without respiratory disease (control group). The two groups were compared using standard bivariate methods. Logistic regression models were used to estimate the cardiovascular risks in COPD patients compared to control group.

RESULTS

Patients with COPD showed a high prevalence of hypertension (72%), dyslipidaemia (73%), obesity (41%), diabetes type 2 (39%), and sleep apnoea syndrome (30%) from mild stages of the disease (GOLD 2009). There was a 22% prevalence of cardiac arrhythmia, 16% of ischaemic heart disease, 16% heart failure, 12% peripheral vascular disease, and 8% cerebrovascular disease. Compared to the control group, patients with COPD had a higher risk of dyslipidaemia (OR 3.24, 95% CI; 2.21-4.75), diabetes type 2 (OR 1.52, 95% CI; 1.01-2,28), and ischaemic heart disease (OR 2.34, 95% CI; 1.22-4.49). In the case of dyslipidaemia, an increased risk was obtained when adjusted for age, gender, and consumption of tobacco (OR 5.04, 95% CI; 2.36-10.74).

CONCLUSIONS

Patients with COPD resident in the Canary Islands have a high prevalence of hypertension, dyslipidaemia, ischaemic heart disease, and cardiac arrhythmia. Compared to general population, patients with COPD have a significant increase in the risk of dyslipidaemia.

摘要

引言

众多研究表明，慢性阻塞性肺疾病（COPD）患者中心血管疾病的患病率很高。本研究的目的是分析加那利群岛诊断为COPD的人群中心血管危险因素和合并症的患病率，并将其与普通人群的数据进行比较。

患者与方法

对300例COPD患者和524例无呼吸系统疾病的受试者（对照组）进行了横断面研究。使用标准双变量方法对两组进行比较。采用逻辑回归模型估计COPD患者与对照组相比的心血管风险。

结果

COPD患者中高血压（72%）、血脂异常（73%）、肥胖（41%）、2型糖尿病（39%）和睡眠呼吸暂停综合征（30%）在疾病轻度阶段（GOLD 2009）的患病率很高。心律失常患病率为22%，缺血性心脏病为16%，心力衰竭为16%，外周血管疾病为12%，脑血管疾病为8%。与对照组相比，COPD患者血脂异常（OR 3.24，95%CI；2.21-4.75）、2型糖尿病（OR 1.52，95%CI；1.01-2.28）和缺血性心脏病（OR 2.34，95%CI；1.22-4.49）的风险更高。就血脂异常而言，在调整年龄、性别和烟草消费后风险增加（OR 5.04，95%CI；2.36-10.74）。