Geldenhuys Elaine, Coldrey Jean, Wright Colleen, Nel Daan, Roberts Drucilla J, Boyd Theonia K, Odendaal Hein
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Division of Anatomical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Int J Gynaecol Obstet. 2017 Jul;138(1):107-112. doi: 10.1002/ijgo.12177. Epub 2017 May 8.
To assess whether fetal foot length at autopsy could reliably indicate gestation duration at stillbirth and the effects of maceration on this method.
The present cross-sectional secondary analysis was part of the Safe Passage Study; all Safe Passage Study participants who experienced a stillbirth at Tygerberg Academic Hospital, Cape Town, South Africa, between August 1, 2007, and January 31, 2015, were eligible to participate. After providing written informed consent for autopsy, the duration of gestation calculated using early ultrasonography and fetal foot length were compared.
There were 69 fetal autopsies included in the present study; placental histology was available for 65. Generally, the gestation length calculated from the first ultrasonography scan correlated well with that calculated from the fetal foot length (Spearman correlation=0.85). However, significant differences were found in the gestation lengths calculated when the fetus was macerated (P<0.001), or when umbilical cord pathology (P<0.001) or maternal vascular malperfusion (P<0.001) was the cause of fetal death.
Foot length at stillbirth was a good indicator of gestation length; however, it was a weaker indicator if fetal maceration had occurred.
评估尸检时胎儿足长能否可靠地指示死产时的妊娠时长以及浸软对该方法的影响。
本横断面二次分析是安全通道研究的一部分;2007年8月1日至2015年1月31日期间在南非开普敦泰格堡学术医院经历死产的所有安全通道研究参与者均符合参与条件。在提供尸检书面知情同意书后,比较了使用早期超声检查计算的妊娠时长和胎儿足长。
本研究纳入了69例胎儿尸检;65例有胎盘组织学检查结果。一般来说,首次超声扫描计算出的妊娠时长与根据胎儿足长计算出的妊娠时长相关性良好(斯皮尔曼相关性=0.85)。然而,当胎儿浸软(P<0.001)、或脐带病变(P<0.001)或母体血管灌注不良(P<0.001)为胎儿死亡原因时,计算出的妊娠时长存在显著差异。
死产时的足长是妊娠时长的良好指标;然而,如果发生胎儿浸软,该指标的指示作用则较弱。