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2015 年全球、区域和国家的死产率估计数及其 2000 年以来的趋势:系统分析。

National, regional, and worldwide estimates of stillbirth rates in 2015, with trends from 2000: a systematic analysis.

机构信息

Maternal Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK; Saving Newborn Lives/Save the Children, Washington, DC, USA.

Maternal Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK.

出版信息

Lancet Glob Health. 2016 Feb;4(2):e98-e108. doi: 10.1016/S2214-109X(15)00275-2. Epub 2016 Jan 19.

Abstract

BACKGROUND

Previous estimates have highlighted a large global burden of stillbirths, with an absence of reliable data from regions where most stillbirths occur. The Every Newborn Action Plan (ENAP) targets national stillbirth rates (SBRs) of 12 or fewer stillbirths per 1000 births by 2030. We estimate SBRs and numbers for 195 countries, including trends from 2000 to 2015.

METHODS

We collated SBR data meeting prespecified inclusion criteria from national routine or registration systems, nationally representative surveys, and other data sources identified through a systematic review, web-based searches, and consultation with stillbirth experts. We modelled SBR (≥28 weeks' gestation) for 195 countries with restricted maximum likelihood estimation with country-level random effects. Uncertainty ranges were obtained through a bootstrap approach.

FINDINGS

Data from 157 countries (2207 datapoints) met the inclusion criteria, a 90% increase from 2009 estimates. The estimated average global SBR in 2015 was 18·4 per 1000 births, down from 24·7 in 2000 (25·5% reduction). In 2015, an estimated 2·6 million (uncertainty range 2·4-3·0 million) babies were stillborn, giving a 19% decline in numbers since 2000 with the slowest progress in sub-Saharan Africa. 98% of all stillbirths occur in low-income and middle-income countries; 77% in south Asia and sub-Saharan Africa.

INTERPRETATION

Progress in reducing the large worldwide stillbirth burden remains slow and insufficient to meet national targets such as for ENAP. Stillbirths are increasingly being counted at a local level, but countries and the global community must further improve the quality and comparability of data, and ensure that this is more clearly linked to accountability processes including the Sustainable Development Goals.

FUNDING

Save the Children's Saving Newborn Lives programme to The London School of Hygiene & Tropical Medicine.

摘要

背景

此前的估计强调了全球范围内大量的死产负担,但在大多数死产发生的地区缺乏可靠的数据。《每个新生儿行动计划》(ENAP)的目标是到 2030 年将全国死产率(SBR)降低到每 1000 例活产 12 例或更少。我们估计了 195 个国家的 SBR 及其数量,包括 2000 年至 2015 年的趋势。

方法

我们从国家常规或登记系统、全国代表性调查以及通过系统评价、网络搜索和与死产专家协商确定的其他数据源中收集符合预先规定纳入标准的 SBR 数据。我们使用受限极大似然估计和国家层面的随机效应模型对 195 个国家的 SBR(≥28 周妊娠)进行建模。通过自举方法获得不确定范围。

发现

来自 157 个国家(2207 个数据点)的数据符合纳入标准,比 2009 年的估计增加了 90%。2015 年全球平均 SBR 估计为每 1000 例活产 18.4 例,低于 2000 年的 24.7 例(下降 25.5%)。2015 年,估计有 260 万(不确定范围为 240 万至 300 万)婴儿死产,自 2000 年以来数量下降了 19%,其中撒哈拉以南非洲地区的进展最慢。所有死产的 98%发生在低收入和中等收入国家;77%发生在南亚和撒哈拉以南非洲。

解释

在减少全球范围内大量死产负担方面,进展仍然缓慢,不足以实现 ENAP 等国家目标。死产在地方一级的统计越来越多,但各国和全球社会必须进一步提高数据的质量和可比性,并确保更明确地将其与包括可持续发展目标在内的问责制进程联系起来。

资助

拯救儿童基金会拯救新生儿生命计划资助伦敦卫生与热带医学院。

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