Putri Denise Utami, Rintiswati Ning, Soesatyo Marsetyawan Hne, Haryana Sofia Mubarika
a Faculty of Medicine, Graduate Program of Medical and Health Science , Universitas Gadjah Mada , Yogyakarta , Indonesia.
b Faculty of Medicine, Department of Microbiology , Universitas Gadjah Mada , Yogyakarta , Indonesia.
Nat Prod Res. 2018 Feb;32(4):463-467. doi: 10.1080/14786419.2017.1311888. Epub 2017 Apr 10.
Disease progression in Tuberculosis (TB) is dependent on host's immune system. Phyllanthus niruri, a traditional herb, has long been used to boost immune system in Indonesian society. This study aimed to observe the potential role of P. niruri in inducing immune cells activity in TB patients by in vitro approach. Peripheral blood mononuclear cells (PBMCs) and macrophages were collected from active pulmonary TB patients. After stimulation with graded doses of P. niruri aqueous extract, cell proliferation, phagocytic activity and nitric oxide (NO) release were analysed. P. niruri aqueous extract induced proliferation of PBMCs, increased NO release, and improved macrophages phagocytic activity. These effects were observed in a dose-dependent manner. This may lead to further research for the potential role of P. niruri as immunomodulatory adjuvant therapy for TB patients.
结核病（TB）的疾病进展取决于宿主的免疫系统。叶下珠，一种传统草药，长期以来在印度尼西亚社会被用于增强免疫系统。本研究旨在通过体外方法观察叶下珠在诱导结核病患者免疫细胞活性方面的潜在作用。从活动性肺结核患者中采集外周血单个核细胞（PBMCs）和巨噬细胞。用不同剂量的叶下珠水提取物刺激后，分析细胞增殖、吞噬活性和一氧化氮（NO）释放。叶下珠水提取物诱导PBMCs增殖，增加NO释放，并改善巨噬细胞吞噬活性。这些作用呈剂量依赖性。这可能会促使进一步研究叶下珠作为结核病患者免疫调节辅助治疗的潜在作用。
