Salazar-Licea Luis Antonio, Pedraza-Ortega Jesús Carlos, Pastrana-Palma Alberto, Aceves-Fernandez Marco A
Facultad de Contaduria y Administracion, Universidad Autonoma de Queretaro, Cerro de Las Campanas S/N, Las Campanas, C.P.76010, Queretaro, Mexico.
Facultad de Ingeniería, Universidad Autonoma de Queretaro, Av. de las Ciencias S/N, Juriquilla, C.P. 76230, Queretaro, Mexico.
Comput Methods Programs Biomed. 2017 May;143:97-111. doi: 10.1016/j.cmpb.2017.02.003. Epub 2017 Feb 24.
There are many work related with segmentation techniques, including nearest neighbor algorithm, fuzzy rules, morphological filters, image entropy, thresholding, machine learning, wavelet analysis, and so on. Such methods carry out the segmentation, but take a lot of processing time by modifying the content of the image or showing discern problems in homogeneous areas, and the segmentation technique is designed to work efficiently only with the techniques used. In this paper a method to segment mammograms in order to separate breast area from pectoral-muscle avoiding bright areas that produce noise and therefore reducing false-positives is presented.
The proposed methodology is divided into four sections: 1) Pre-processing to acquire image and decreasing its size. 2) Improving the image quality through image thresholding and histogram equalization. 3) Localization of regions of interest (ROI) applying Scale-Invariant Feature Transform to find image's descriptors. Clustering methods were implemented to determine the best number of clusters and which of these represent the most significant breast area. Then found ROI's coordinates are compared with the position of abnormalities diagnosed by the Mammographic Image Analysis Society. 4) Microcalcifications (mcc) detection; wavelet transform is used, and to enhance its performance different high-pass filters and high-frequency emphasis filters are evaluated. Symlet wavelets: Sym8 and Sym16 were used with different decomposition level; images results from both processes are compared and only those elements in common are detected as microcalcifications.
Moreover, muscle's remnants in the corners of the regions of interest were removed using fuzzy c-means clustering. The best results in terms of sensitivity (91.27), false-positives per image (80.25), and precision (74.38) are compared with previous work.
Results shows that the breast area can be discriminated from the pectoral-muscle by avoiding to work with brightness areas that produces false positives. Moreover, because the image size is reduced the computer processing time will be decreased. This segmentation stage can be an addition to mammograms analysis broadly, not only to find mcc but abnormalities such as circumscribed masses, speculated masses and architectural distortion. Also is useful to create automatically an unsupervised segmentation in mammograms without stage of training.
有许多与分割技术相关的工作,包括最近邻算法、模糊规则、形态学滤波器、图像熵、阈值处理、机器学习、小波分析等。这些方法可进行分割,但通过修改图像内容或在均匀区域显示识别问题会耗费大量处理时间,并且分割技术仅针对所使用的技术设计以高效运行。本文提出了一种用于分割乳腺X线照片的方法,以便将乳腺区域与胸肌分离,避免产生噪声的明亮区域,从而减少假阳性。
所提出的方法分为四个部分:1)预处理以获取图像并减小其尺寸。2)通过图像阈值处理和直方图均衡化提高图像质量。3)应用尺度不变特征变换定位感兴趣区域(ROI)以找到图像的描述符。实施聚类方法以确定最佳聚类数以及其中哪些代表最重要的乳腺区域。然后将找到的ROI坐标与乳腺影像分析协会诊断的异常位置进行比较。4)微钙化(mcc)检测;使用小波变换,并评估不同的高通滤波器和高频增强滤波器以提高其性能。使用Symlet小波:Sym8和Sym16并采用不同的分解级别;比较两个过程的图像结果,仅将那些共同的元素检测为微钙化。
此外,使用模糊c均值聚类去除了感兴趣区域角落中的肌肉残余。将在灵敏度(91.27)、每张图像的假阳性(80.25)和精度(74.38)方面的最佳结果与先前的工作进行了比较。
结果表明,通过避免处理产生假阳性的明亮区域,可以将乳腺区域与胸肌区分开来。此外,由于图像尺寸减小,计算机处理时间将减少。这个分割阶段可以广泛地作为乳腺X线照片分析的补充,不仅用于发现微钙化,还用于发现诸如局限性肿块、推测性肿块和结构扭曲等异常。它也有助于在没有训练阶段的情况下自动创建乳腺X线照片的无监督分割。