Lilja F, Mani K, Wanhainen A
Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University, Uppsala, Sweden.
Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University, Uppsala, Sweden.
Eur J Vasc Endovasc Surg. 2017 Jun;53(6):811-819. doi: 10.1016/j.ejvs.2017.02.031. Epub 2017 Apr 5.
The epidemiology and management of abdominal aortic aneurysms (AAAs) has changed drastically in the past decades, with implementation of nationwide screening programs, introduction of endovascular repair (EVAR), and reduced prevalence of the disease. This report aims to assess recent trends in AAA repair epidemiology in Sweden in this context.
Primary AAA repairs registered in the nationwide Swedish Vascular Registry (Swedvasc) 1994-2014 were analyzed regarding patient characteristics, repair incidence, technique, and outcome. Four time periods were compared: 1994-1999, 2000-2004, 2005-2009, and 2010-2014.
The incidence of intact AAA repair increased (18.4/100,000 1994-1999, 27.3/100,000 2010-2014, p < .001) predominantly among octogenarians (12.7/100,000 1994-1999, 36.0/100,000 2010-2014, p < .001). The utilization of EVAR increased (58% of all intact AAA repairs 2010-2014), especially among octogenarians (80% 2010-2014). During the last time period, however, the incidence of intact AAA repair stabilized, despite an increasing number of screening-detected AAAs operated on (19% in 2010-2014). Short- and long-term outcome after intact AAA repair continued to improve, most pronounced among octogenarians (30-day mortality 9% 1994-1999, 2% 2010-2014, p < .001). The incidence of ruptured AAA repair steadily decreased (9.2/100,000 1994-1999, 6.9/100,000 2010-2014, p < .001) and the use of EVAR for ruptures increased (30% in 2010-2014). The previously observed improvement of short- and long-term outcome after ruptured AAA repair (30-day mortality 38% 1994-1999, 28% 2010-2014, p < .001) stalled during the last time period. The overall 30-day mortality after ruptured AAA repair was 22% after EVAR versus 31% after open repair in 2010-2014. The corresponding mortality for octogenarians was 28% versus 42%.
For the first time, a halt in intact AAA repair workload could be identified. This trend-break occurred despite continued increase in treatment of octogenarians and screening-detected aneurysms. Additionally, the ruptured AAA repair incidence continued to decrease. These findings, together with the sustained improvement in survival after AAA repair, may have important impact on planning of vascular surgical services.
在过去几十年中,腹主动脉瘤(AAA)的流行病学和治疗方式发生了巨大变化,全国性筛查项目得以实施,血管内修复术(EVAR)被引入,且该疾病的患病率有所降低。本报告旨在评估在此背景下瑞典AAA修复流行病学的近期趋势。
分析1994 - 2014年瑞典全国血管登记处(Swedvasc)登记的原发性AAA修复手术,内容涉及患者特征、修复发生率、技术及结果。比较了四个时间段:1994 - 1999年、2000 - 2004年、2005 - 2009年和2010 - 2014年。
完整AAA修复的发生率有所上升(1994 - 1999年为18.4/10万,2010 - 2014年为27.3/10万,p <.001),主要是在八旬老人中(1994 - 1999年为12.7/10万,2010 - 2014年为36.0/10万,p <.001)。EVAR的使用率增加(2010 - 2014年所有完整AAA修复手术的58%),尤其是在八旬老人中(2010 - 2014年为80%)。然而,在最后一个时间段,尽管接受手术的筛查发现的AAA数量增加(2010 - 2014年为19%),完整AAA修复的发生率却趋于稳定。完整AAA修复后的短期和长期结果持续改善,在八旬老人中最为显著(1994 - 1999年30天死亡率为9%,2010 - 2014年为2%,p <.001)。破裂AAA修复的发生率稳步下降(1994 - 1999年为9.2/10万,2010 - 2014年为6.9/10万,p <.001),且EVAR用于破裂AAA修复的比例增加(2010 - 2014年为30%)。之前观察到的破裂AAA修复后短期和长期结果的改善(1994 - 1999年30天死亡率为38%,2010 - 2014年为28%,p <.001)在最后一个时间段停滞不前。2010 - 2014年,破裂AAA修复后接受EVAR治疗的总体30天死亡率为22%,而开放修复后为31%。八旬老人的相应死亡率分别为28%和42%。
首次发现完整AAA修复工作量出现停滞。尽管八旬老人和筛查发现的动脉瘤的治疗持续增加,但仍出现了这种趋势转变。此外,破裂AAA修复的发生率继续下降。这些发现,连同AAA修复后生存率的持续提高,可能对血管外科服务的规划产生重要影响。