Gavali H, Mani K, Tegler G, Kawati R, Covaciu L, Wanhainen A
Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University, Uppsala, Sweden.
Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University, Uppsala, Sweden.
Eur J Vasc Endovasc Surg. 2017 Aug;54(2):157-163. doi: 10.1016/j.ejvs.2017.05.014. Epub 2017 Jun 23.
The aim of the study was to investigate the frequency and outcome of prolonged intensive care unit (ICU) length of stay (LOS) after abdominal aortic aneurysm (AAA) repair in the endovascular era.
All patients operated on for AAA between 1999 and 2013 at Uppsala University hospital were identified. Data were retrieved from the Swedish Vascular registry, the Swedish Intensive Care registry, the National Population registry, and case records. Prolonged ICU LOS was defined as ≥ 48 h during the primary hospital stay. Patients surviving ≥ 48 h after AAA surgery were included in the analysis.
A total of 725 patients were identified, of whom 707 (97.5%) survived ≥ 48 h; 563 (79.6%) underwent intact AAA repair and 144 (20.4%) ruptured AAA repair. A total of 548 patients (77.5%) required < 48 h of intensive care, 115 (16.3%) 2-6 days and 44 (6.2%) ≥ 7 days. The rate of prolonged ICU LOS declined considerably over time, from 41.4% of all AAA repairs in 1999 to 7.3% in 2013 (p < .001) whereas the use of endovascular aortic repair (EVAR) increased from 6.9% in 1999 to 78.0% in 2013 (p < .001). The 30 day survival rate was 98.2% for those with < 48 h ICU stay versus 93.0% for 2-6 days versus 81.8% for ≥ 7 days (p < .001); the corresponding 90 day survival was 97.1% versus 86.1% versus 63.6% (p < .001) respectively. For patients surviving 90 days after repair, there was no difference in long-term survival between the groups.
During the period of progressively increasing use of EVAR, a simultaneous significant reduction in frequency of prolonged ICU LOS occurred. Although prolonged ICU LOS was associated with a high short-term mortality, long-term outcome among those surviving the initial 90 days was less affected.
本研究旨在调查血管腔内修复时代腹主动脉瘤(AAA)修复术后重症监护病房(ICU)住院时间延长(LOS)的频率及结果。
确定1999年至2013年在乌普萨拉大学医院接受AAA手术的所有患者。数据取自瑞典血管登记处、瑞典重症监护登记处、国家人口登记处及病例记录。延长的ICU住院时间定义为初次住院期间≥48小时。AAA手术后存活≥48小时的患者纳入分析。
共确定725例患者,其中707例(97.5%)存活≥48小时;563例(79.6%)接受完整AAA修复,144例(20.4%)接受破裂AAA修复。共548例患者(77.5%)需要<48小时的重症监护,115例(16.3%)需要2至6天,44例(6.2%)需要≥7天。延长的ICU住院时间发生率随时间显著下降,从1999年所有AAA修复手术的41.4%降至2013年的7.3%(p<0.001),而血管腔内主动脉修复(EVAR)的使用率从1999年的6.9%增至2013年的78.0%(p<0.001)。ICU住院时间<48小时的患者30天生存率为98.2%,2至6天的为93.0%,≥7天的为81.8%(p<0.001);相应的90天生存率分别为97.1%、86.1%和63.6%(p<0.001)。对于修复后存活90天的患者,各亚组间长期生存率无差异。
在EVAR使用逐渐增加的时期,延长的ICU住院时间发生率同时显著降低。虽然延长的ICU住院时间与高短期死亡率相关,但最初90天存活患者的长期结局受影响较小。