Kistenmacher Alina, Manneck Sebastian, Wardzinski Ewelina K, Martens Jan C, Gohla Georg, Melchert Uwe H, Jauch-Chara Kamila, Oltmanns Kerstin M
Section of Psychoneurobiology, University of Luebeck, Luebeck, Germany.
Section of Psychoneurobiology, University of Luebeck, Luebeck, Germany.
Brain Stimul. 2017 Jul-Aug;10(4):780-786. doi: 10.1016/j.brs.2017.03.011. Epub 2017 Mar 25.
Transcranial direct current stimulation (tDCS) of the human brain increases systemic glucose tolerance.
OBJECTIVE/HYPOTHESIS: To investigate whether this effect persists after one week of repeated stimulation. Because systemic glucose uptake relates to brain energy homeostasis, we concomitantly measured cerebral high-energy phosphate metabolites.
In a sham-controlled crossover design, 14 healthy men were tested under daily anodal tDCS vs. sham for 8 days. Systemic glucose metabolism was examined by concentrations of circulating glucose and insulin. Cerebral energy metabolism - i.e. adenosine triphosphate (ATP) and phosphocreatine (PCr) levels - was assessed by phosphorous magnetic resonance spectroscopy.
Blood glucose concentrations were distinctly lower upon tDCS compared with sham stimulation on day 1. This effect persisted on day 8, while serum insulin levels remained persistently unchanged. Transcranial stimulation increased mean levels of ATP and PCr compared with sham on day 1 only. Blood glucose concentrations negatively correlated with PCr content after repeated daily stimulation.
Our data confirm that tDCS reduces blood glucose through an insulin-independent mechanism. This effect persists after 8 days of repeated stimulation and relates to brain energy metabolism. Therefore, transcranial electric stimulation may be a promising non-pharmacological adjuvant option to treat systemic disorders such as glucose intolerance or type 2 diabetes mellitus with a low side-effect profile.
对人脑进行经颅直流电刺激（tDCS）可提高全身葡萄糖耐量。
目的/假设：研究重复刺激一周后这种效应是否持续存在。由于全身葡萄糖摄取与脑能量稳态相关，我们同时测量了脑高能磷酸代谢物。
在一项假刺激对照的交叉设计中，14名健康男性分别在每日阳极tDCS和假刺激条件下接受测试，为期8天。通过循环葡萄糖和胰岛素浓度检测全身葡萄糖代谢。通过磷磁共振波谱评估脑能量代谢，即三磷酸腺苷（ATP）和磷酸肌酸（PCr）水平。
在第1天，与假刺激相比，tDCS时血糖浓度明显更低。这种效应在第8天持续存在，而血清胰岛素水平持续保持不变。仅在第1天，与假刺激相比，经颅刺激增加了ATP和PCr的平均水平。每日重复刺激后，血糖浓度与PCr含量呈负相关。
我们的数据证实，tDCS通过非胰岛素依赖机制降低血糖。这种效应在重复刺激8天后持续存在，且与脑能量代谢相关。因此，经颅电刺激可能是一种有前景的非药物辅助选择，用于治疗葡萄糖不耐受或2型糖尿病等全身疾病，且副作用较小。
