Yonezawa S, Maruyama I, Tanaka S, Nakamura T, Sato E
Department of Pathology, Kagoshima University School of Medicine, Japan.
Cancer. 1988 Aug 1;62(3):569-76. doi: 10.1002/1097-0142(19880801)62:3<569::aid-cncr2820620322>3.0.co;2-t.
Thrombomodulin (TM) is a newly described protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. TM is found on endothelium of the blood and lymph vessels and on syncytiotrophoblast of the placenta in humans. In the current study, we localized TM by immunohistochemistry in chorionic diseases of the uterus and choriocarcinomas of the stomach. The syncytiotrophoblast of hydatidiform mole contained TM. Uterine choriocarcinoma also had TM in the neoplastic syncytiotrophoblastic cells, although some of the neoplastic syncytiotrophoblastic cells showed no TM expression. Gastric choriocarcinoma never showed TM expression in the neoplastic syncytiotrophoblastic cells. However, all of the syncytiotrophoblastic cells had human chorionic gonadotropin (hCG) in hydatidiform mole, uterine choriocarcinoma, and gastric choriocarcinoma.
血栓调节蛋白（TM）是一种新发现的蛋白质，它通过将凝血酶从促凝蛋白酶转化为抗凝剂，发挥强大的天然抗凝作用。TM存在于人类的血液和淋巴管内皮以及胎盘的合体滋养层细胞上。在本研究中，我们通过免疫组织化学方法在子宫绒毛膜疾病和胃绒毛膜癌中定位TM。葡萄胎的合体滋养层细胞含有TM。子宫绒毛膜癌的肿瘤性合体滋养层细胞中也有TM，尽管部分肿瘤性合体滋养层细胞未显示TM表达。胃绒毛膜癌的肿瘤性合体滋养层细胞从未显示TM表达。然而，在葡萄胎、子宫绒毛膜癌和胃绒毛膜癌中，所有的合体滋养层细胞均有人类绒毛膜促性腺激素（hCG）。
