Wu C I, Lyttle T W, Wu M L, Lin G F
Department of Biology, University of Rochester, New York 14627.
Cell. 1988 Jul 15;54(2):179-89. doi: 10.1016/0092-8674(88)90550-8.
A large array of satellite DNA sequences are always associated with the Responder (Rsp) element of Segregation Distorter in D. melanogaster. In the appropriate genetic backgrounds, Rsp causes aberrant chromatin condensation in spermiogenesis, leading to dysfunction of sperm carrying Rsp, and meiotic drive. The repeat array is deleted or translocated to the Y chromosome whenever Rsp is. Moreover, the translocation of part of Rsp to Y is associated with the translocation of an incomplete repeat array. The number of repeats among 35 independently derived chromosomes correlates nearly perfectly with sensitivity to distortion. We hypothesize that this satellite repeat array represents Responder itself. Finally, the molecular structure of this locus is extremely variable, indicating a very active process of change.
大量的卫星DNA序列总是与黑腹果蝇中分离畸变因子的响应者（Rsp）元件相关联。在合适的遗传背景下，Rsp在精子发生过程中导致异常的染色质浓缩，从而导致携带Rsp的精子功能障碍以及减数分裂驱动。每当Rsp出现时，重复序列阵列就会被删除或易位到Y染色体上。此外，Rsp的一部分易位到Y染色体与一个不完整的重复序列阵列的易位相关。在35条独立衍生的染色体中，重复序列的数量与畸变敏感性几乎完全相关。我们推测这个卫星重复序列阵列代表了响应者本身。最后，这个位点的分子结构极其多变，表明其变化过程非常活跃。
