母亲童年期受虐待经历与配偶选择有关：对后代自闭症的影响。
Maternal Exposure to Childhood Abuse is Associated with Mate Selection: Implications for Autism in Offspring.
作者信息
Roberts Andrea L, Lyall Kristen, Weisskopf Marc G
机构信息
Department of Society, Human Development and Health, Harvard T. H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
出版信息
J Autism Dev Disord. 2017 Jul;47(7):1998-2009. doi: 10.1007/s10803-017-3115-3.
Maternal experience of childhood abuse has been associated with offspring autism. To explore whether familial tendency towards autistic traits-presumably related to genetic predisposition-accounts for this association, we examined whether women who experienced childhood abuse were more likely to select mates with high levels of autistic traits, and whether parental autistic traits accounted for the association of maternal abuse and offspring autism in 209 autism cases and 833 controls. Maternal childhood abuse was strongly associated with high paternal autistic traits (severe abuse, OR = 3.98, 95% CI = 1.26, 8.31). Maternal and paternal autistic traits accounted for 21% of the association between maternal abuse and offspring autism. These results provide evidence that childhood abuse affects mate selection, with implications for offspring health.
母亲童年期受虐待的经历与后代患自闭症有关。为了探究自闭症特征的家族倾向（可能与遗传易感性有关）是否能解释这种关联，我们研究了童年期受虐待的女性是否更有可能选择具有高自闭症特征水平的配偶，以及在209例自闭症病例和833例对照中，父母的自闭症特征是否能解释母亲受虐待与后代自闭症之间的关联。母亲童年期受虐待与父亲的高自闭症特征密切相关（严重虐待，比值比=3.98，95%置信区间=1.26，8.31）。母亲和父亲的自闭症特征占母亲受虐待与后代自闭症之间关联的21%。这些结果提供了证据，表明童年期受虐待会影响配偶选择，对后代健康有影响。
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