Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
J Oral Pathol Med. 2017 Nov;46(10):967-971. doi: 10.1111/jop.12579. Epub 2017 May 9.
c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue.
Immunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein. Staining was evaluated by multiplying the percentage of c-MYC-expressing cells with staining intensity, giving a quick score for each tumour.
All 104 tumours expressed c-MYC at varying levels. Quantitation according to per cent of positive cells and staining intensity revealed that most (15/21; 71%) high-expressing tumours were seen in males. Within the group of high c-MYC-expressing tumours, the majority were alive 2 and 5 years after treatment.
The present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.
c-MYC 是一种具有多种细胞功能的强效癌蛋白，如分化、凋亡和生长调控。MYC 基因的失调在人类肿瘤中很常见，导致蛋白过度表达。在这里，我们研究了 c-MYC 在原发性舌鳞癌患者中的表达与临床结局的相关性。
使用针对蛋白 N 端的抗体，通过免疫组织化学方法检测 104 例舌鳞癌中的 c-MYC。通过将表达 c-MYC 的细胞百分比与染色强度相乘，为每个肿瘤计算一个快速评分来评估染色。
104 例肿瘤均在不同水平表达 c-MYC。根据阳性细胞百分比和染色强度进行定量，发现大多数（15/21；71%）高表达肿瘤发生于男性。在高 c-MYC 表达肿瘤组中，大多数患者在治疗后 2 年和 5 年时仍存活。
本研究结果表明，c-MYC 的表达在舌鳞癌中有预后价值，可能有助于选择治疗方案。
