Department of Chemistry, University of Alberta , Edmonton, Alberta, Canada T6G 2G2.
Org Lett. 2017 Apr 21;19(8):1950-1953. doi: 10.1021/acs.orglett.7b00291. Epub 2017 Apr 10.
Several coenzyme A (CoA) analogues are made in a single step under mild conditions via transamidation reactions catalyzed by boric acid in water. This approach offers rapid access to compounds useful for the study of a wide spectrum of enzyme catalyzed reactions, especially processes involving acyl carrier proteins (ACP) of polyketide synthases (PKS), fatty acid synthases (FAS), and nonribosomal peptide synthetases (NRPS). The CoA analogues presented are readily elaborated or extended by precedented reactions for specific applications that may be required.
几种辅酶 A (CoA) 类似物可在温和条件下通过硼酸在水中催化的转酰胺反应一步合成。这种方法为研究广泛的酶催化反应，特别是涉及聚酮合酶 (PKS)、脂肪酸合酶 (FAS) 和非核糖体肽合酶 (NRPS) 的酰基载体蛋白 (ACP) 的过程中有用的化合物提供了快速途径。所呈现的 CoA 类似物可通过已有反应进行修饰或扩展，以满足特定应用的需要。
