Varey A M, Lydyard P M, Dean B M, Van der Meide P H, Baird J D, Cooke A
Department of Immunology, Middlesex Hospital Medical School, London, England.
Diabetes. 1988 Feb;37(2):209-12. doi: 10.2337/diab.37.2.209.
The ability of recombinant interferon-gamma (rIFN-gamma) to induce major histocompatibility complex (MHC) antigen expression in the rat insulinoma cell line RINm5F was investigated. The cells were stained with monoclonal antibodies specific for rat class I and class II MHC antigens. RINm5F cells endogenously expressed class I antigens; this was enhanced by rIFN-gamma. Class II antigens could not be detected on RINm5F cells, but both I-A and I-E were induced by rIFN-gamma.
研究了重组干扰素-γ（rIFN-γ）诱导大鼠胰岛素瘤细胞系RINm5F中主要组织相容性复合体（MHC）抗原表达的能力。用针对大鼠I类和II类MHC抗原的单克隆抗体对细胞进行染色。RINm5F细胞内源性表达I类抗原；rIFN-γ可增强这种表达。在RINm5F细胞上未检测到II类抗原，但rIFN-γ可诱导I-A和I-E的表达。
