Su Yanhua, Jackson Todd, Wei Dongtao, Qiu Jiang, Chen Hong
Department of Psychology, Southwest UniversityChongqing, China; School of Management, Zunyi Medical UniversityZunyi, China.
Department of Psychology, Southwest UniversityChongqing, China; Department of Psychology, University of MacauTaipa, China.
Front Psychol. 2017 Mar 27;8:443. doi: 10.3389/fpsyg.2017.00443. eCollection 2017.
Participants were non-clinical young adults with different restrained eating levels.We assessed relations of restrained eating (RE) with regional gray matter volume (rGMV).High RE scores were related to larger GMV in specific areas related to reward.High RE scores were also linked to less GMV in regions related to response inhibition. Dieting is a popular method of weight control. However, few dieters are able to maintain initial weight losses over an extended period of time. Why do most restrained dieters fail to lose weight? Alterations in brain structures associated with restrained eating (RE) represent one potentially important mechanism that contributes to difficulties in maintaining weight loss within this group. To evaluate this contention, we investigated associations between intentional, sustained restriction of food intake to lose or maintain body weight, and regional gray matter volume (rGMV) within a large non-clinical young adult, sample. Participants (150 women, 108 men) completed measures of RE and demographics prior to undergoing an MRI scan. Voxel-based morphometry (VBM) evaluated strengths of association between RE scores and rGMV. Higher RE levels corresponded to more rGMV in regions linked to risk of overeating and binge-eating including the left insula and orbitofrontal cortex (OFC). Conversely, RE had significant negative correlations with rGMV in the left and right posterior cingulum gyrus, regions linked to inhibitory control and potential risk for future weight gain. Together, findings suggested individual differences in RE among young adults correspond to GMV variability in regions linked to overweight and obesity risk.
参与者为具有不同节食水平的非临床年轻成年人。我们评估了节食与区域灰质体积（rGMV）之间的关系。高节食得分与奖励相关的特定区域中较大的灰质体积有关。高节食得分还与反应抑制相关区域中较少的灰质体积有关。节食是一种流行的体重控制方法。然而，很少有节食者能够在较长时间内维持最初的体重减轻。为什么大多数节食者减肥失败？与节食相关的大脑结构改变是导致该群体难以维持体重减轻的一个潜在重要机制。为了评估这一论点，我们在一个大型非临床年轻成年人样本中，研究了为减轻或维持体重而有意、持续限制食物摄入量与区域灰质体积（rGMV）之间的关联。参与者（150名女性，108名男性）在进行MRI扫描前完成了节食和人口统计学测量。基于体素的形态计量学（VBM）评估了节食得分与rGMV之间的关联强度。较高的节食水平与与暴饮暴食风险相关的区域中更多的rGMV相对应，这些区域包括左侧岛叶和眶额皮质（OFC）。相反，节食与左右后扣带回中的rGMV呈显著负相关，这些区域与抑制控制以及未来体重增加的潜在风险有关。总之，研究结果表明，年轻成年人中节食的个体差异与与超重和肥胖风险相关区域的灰质体积变异性相对应。
