Dong Debo, Jackson Todd, Wang Yulin, Chen Hong
Key Laboratory of Cognition and Personality (Ministry of Education), Southwest University, Chongqing 400715, China; School of Psychology, Southwest University, Chongqing 400715, China.
Key Laboratory of Cognition and Personality (Ministry of Education), Southwest University, Chongqing 400715, China; School of Psychology, Southwest University, Chongqing 400715, China.
Biol Psychol. 2015 Jul;109:176-83. doi: 10.1016/j.biopsycho.2015.05.003. Epub 2015 May 21.
Theory and prospective studies have linked restrained eating (RE) to risk for future weight gain and the onset of obesity, but little is known about resting state neural activity that may underlie this association. To address this gap, resting fMRI was used to test the extent to which spontaneous neural activity in regions associated with inhibitory control and food reward account for potential relations between baseline RE levels and changes in body weight among dieters over a one-year interval. Spontaneous regional activity patterns corresponding to RE were assessed among 50 young women using regional homogeneity (ReHo) analysis, which measured temporal synchronization of spontaneous fluctuations within a food deprivation condition. Analyses indicated higher baseline RE scores predicted more weight gain at a one-year follow-up. Furthermore, food-deprived dieting women with high dietary restraint scores exhibited more spontaneous local activity in brain regions associated with the expectation and valuation for food reward [i.e., orbitofrontal cortex (OFC)/ventromedial prefrontal cortex (VMPFC)] and reduced spontaneous local activity in inhibitory control regions [i.e., bilateral dorsal-lateral prefrontal cortex (DLPFC)] at baseline. Notably, the association between baseline RE and follow-up weight gain was mediated by decreased local synchronization of the right DLPFC in particular and, to a lesser degree, increased local synchronization of the right VMPFC. In conjunction with previous research, these findings highlight possible neural mechanisms underlying the relation between RE and risk for weight gain.
理论和前瞻性研究已将节制饮食（RE）与未来体重增加和肥胖症的发病风险联系起来，但对于可能构成这种关联基础的静息态神经活动却知之甚少。为了填补这一空白，研究人员使用静息态功能磁共振成像（fMRI）来测试与抑制控制和食物奖励相关区域的自发神经活动在多大程度上解释了节食者在一年时间间隔内基线RE水平与体重变化之间的潜在关系。在50名年轻女性中，使用局部一致性（ReHo）分析评估了与RE相对应的自发区域活动模式，该分析测量了食物剥夺条件下自发波动的时间同步性。分析表明，较高的基线RE分数预测在一年随访中体重增加更多。此外，在基线时，饮食节制得分高的节食女性在与食物奖励的期望和评估相关的脑区[即眶额皮质（OFC）/腹内侧前额叶皮质（VMPFC）]表现出更多的自发局部活动，而在抑制控制区域[即双侧背外侧前额叶皮质（DLPFC）]的自发局部活动减少。值得注意的是，基线RE与随访体重增加之间的关联尤其由右侧DLPFC局部同步性降低介导，在较小程度上也由右侧VMPFC局部同步性增加介导。结合先前的研究，这些发现突出了RE与体重增加风险之间关系的潜在神经机制。
