Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Subproject A1, CRC1052 "Obesity Mechanisms", University of Leipzig, Leipzig, Germany.
Hum Brain Mapp. 2019 Jun 15;40(9):2747-2758. doi: 10.1002/hbm.24557. Epub 2019 Feb 28.
The food addiction model suggests neurobiological similarities between substance-related and addictive disorders and obesity. While structural brain differences have been consistently reported in these conditions, little is known about the neuroanatomical correlates of food addiction. We therefore aimed to determine whether symptoms of food addiction related to body mass index (BMI), personality, and brain structure in a large population-based sample. Participants of the LIFE-Adult study (n = 625; 20-59 years old, 45% women) answered the Yale Food Addiction Scale (YFAS) and further personality measures, underwent anthropometric assessments and high-resolution 3T-neuroimaging. A higher YFAS symptom score correlated with higher BMI, eating behavior traits, neuroticism, and stress. Higher BMI predicted significantly lower thickness of (pre)frontal, temporal and occipital cortex and increased volume of left nucleus accumbens. In a whole-brain analysis, YFAS symptom score was not associated with significant differences in cortical thickness or subcortical gray matter volumes. A hypothesis-driven Bayes factor analysis suggested a small, additional contribution of YFAS symptom score to lower right lateral orbitofrontal cortex thickness over the effect of BMI. Our study indicates that symptoms of food addiction do not account for the major part of the structural brain differences associated with BMI in the general population. Yet, symptoms of food addiction might explain additional variance in orbitofrontal cortex, a hub area of the reward network. Longitudinal studies implementing both anatomical and functional MRI could further disentangle the neural mechanisms of addictive eating behaviors.
食物成瘾模型表明，物质相关和成瘾障碍与肥胖之间存在神经生物学相似性。虽然这些疾病的结构大脑差异一直被报道，但对食物成瘾的神经解剖学相关性知之甚少。因此，我们旨在确定在大型基于人群的样本中，食物成瘾症状是否与体重指数（BMI）、个性和大脑结构有关。LIFE-Adult 研究的参与者（n=625；20-59 岁，45%为女性）回答了耶鲁食物成瘾量表（YFAS）和其他个性测量，进行了人体测量评估和高分辨率 3T 神经影像学检查。较高的 YFAS 症状评分与较高的 BMI、饮食行为特征、神经质和压力相关。较高的 BMI 显著预测（额）前、颞和枕叶皮质的厚度降低，以及左侧伏隔核体积增加。在全脑分析中，YFAS 症状评分与皮质厚度或皮质下灰质体积无显著差异相关。基于假设的贝叶斯因子分析表明，YFAS 症状评分对右侧外侧眶额皮质厚度的影响较小，而 BMI 的影响较大。我们的研究表明，食物成瘾症状并不能解释与一般人群 BMI 相关的大部分大脑结构差异。然而，食物成瘾症状可能解释了眶额皮质（奖励网络的枢纽区域）中额外的差异。实施解剖学和功能 MRI 的纵向研究可以进一步阐明成瘾性饮食行为的神经机制。
