Chen Mitchell, Mattar Gaith, Abdulkarim Jamal A
Mitchell Chen, Jamal A Abdulkarim, Department of Radiology, George Eliot Hospital NHS Trust, Nuneaton, Warwickshire CV10 7DJ, United Kingdom.
World J Radiol. 2017 Mar 28;9(3):143-147. doi: 10.4329/wjr.v9.i3.143.
To evaluate the feasibility of reducing the dose of iodinated contrast agent in computed tomography pulmonary angiography (CTPA).
One hundred and twenty-seven patients clinically suspected of having pulmonary embolism underwent spiral CTPA, out of whom fifty-seven received 75 mL and the remaining seventy a lower dose of 60 mL of contrast agent. Both doses were administered in a multiphasic injection. A minimum opacification threshold of 250 Hounsfield units (HU) in the main pulmonary artery is used for assessing the technical adequacy of the scans.
Mean opacification was found to be positively correlated to patient age (Pearson's correlation 0.4255, < 0.0001) and independent of gender (male:female, 425.6 450.4, = 0.34). When age is accounted for, the study and control groups did not differ significantly in their mean opacification in the main (436.8 437.9, = 0.48), left (416.6 419.8, = 0.45) or the right pulmonary arteries (417.3 423.5, = 0.40). The number of sub-optimally opacified scans (the mean opacification in the main pulmonary artery < 250 HU) did not differ significantly between the study and control groups (7 10).
A lower dose of iodine contrast at 60 mL can be feasibly used in CTPA without resulting in a higher number of sub-optimally opacified scans.
评估在计算机断层扫描肺动脉造影（CTPA）中降低碘造影剂剂量的可行性。
127例临床怀疑有肺栓塞的患者接受了螺旋CTPA检查，其中57例接受75毫升造影剂，其余70例接受较低剂量的60毫升造影剂。两种剂量均采用多期注射。以主肺动脉最低250亨氏单位（HU）的密度值作为评估扫描技术是否充分的标准。
发现平均密度值与患者年龄呈正相关（皮尔逊相关系数0.4255，<0.0001），且与性别无关（男：女，425.6对450.4，P = 0.34）。考虑年龄因素后，研究组和对照组在主肺动脉（436.8对437.9，P = 0.48）、左肺动脉（416.6对419.8，P = 0.45）或右肺动脉（417.3对423.5，P = 0.40）的平均密度值上无显著差异。研究组和对照组中密度值欠佳的扫描次数（主肺动脉平均密度值<250 HU）无显著差异（7对10）。
在CTPA中可行地使用60毫升的低剂量碘造影剂，不会导致密度值欠佳的扫描次数增加
