State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou, 730000, People's Republic of China.
Top Curr Chem (Cham). 2017 Apr;375(2):49. doi: 10.1007/s41061-017-0137-4. Epub 2017 Apr 10.
Ureas are an important class of bioactive organic compounds in organic chemistry and exist widely in natural products, agricultural pesticides, uron herbicides, pharmaceuticals. Even though urea itself has been synthesized from CO and ammonia for a long time, the selective and efficient synthesis of substituted ureas is still challenging due to the difficulty of dehydration processes. Efficient and economic fixation of CO is of great importance in solving the problems of resource shortages, environmental issues, global warming, etc. During recent decades, chemists have developed different catalytic systems to synthesize ureas from CO and amines. Herein, we focus on catalytic synthesis of ureas using CO and amines.
脲类化合物是有机化学中一类重要的生物活性有机化合物，广泛存在于天然产物、农业杀虫剂、尿嘧啶除草剂和药物中。尽管尿素本身已经可以通过一氧化碳和氨长期合成，但由于脱水过程的困难，取代脲的选择性和高效合成仍然具有挑战性。高效、经济地固定 CO 在解决资源短缺、环境问题、全球变暖等问题方面具有重要意义。在过去几十年中，化学家已经开发出不同的催化体系，以 CO 和胺为原料合成脲类化合物。在此，我们重点介绍使用 CO 和胺催化合成脲的方法。
