通过将 [11C]CO2 掺入脂肪族和芳族胺中，快速有效地合成 [11C]脲。
Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines.
机构信息
Division of Imaging Sciences and Biomedical Engineering, King's College London, UK SE1 7EH.
出版信息
Chem Commun (Camb). 2013 Sep 25;49(74):8193-5. doi: 10.1039/c3cc44046j.
PMID:23925577
Abstract
A rapid urea radiolabelling methodology has been developed. [(11)C]CO2 was activated by 1,8-diazabicycloundec-7-ene (DBU) in the presence of aliphatic and aromatic amines and reacted with Mitsunobu reagents to produce asymmetric (11)C radiolabelled ureas in high radiochemical yields.
摘要
已开发出一种快速尿素放射性标记方法。[(11)C]CO2 在 1,8-二氮杂二环[5.4.0]十一碳-7-烯 (DBU) 的存在下与脂肪族和芳香族胺激活，并与 Mitsunobu 试剂反应，以高产率生成不对称的[(11)C]放射性标记尿素。
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